Identify the serum lithium level for maintenance and safety.

Choice A reason: Mutism, the absence of speech, is not typical in acute mania, where dopamine-driven hyperactivity increases verbal output. Mutism is more associated with catatonia or severe depression, where psychomotor inhibition or serotonin deficits reduce communication, making this inconsistent with mania’s neurobiological profile.

Choice B reason: Flight of ideas, characterized by rapid, disjointed speech, typifies acute mania due to dopamine and norepinephrine hyperactivity in the prefrontal cortex and limbic system. This leads to accelerated thought processes and pressured speech, reflecting the manic state’s heightened neural excitability and reduced inhibitory control.

Choice C reason: Hesitant speech is not characteristic of acute mania, where dopamine-driven hyperactivity results in rapid, pressured speech. Hesitancy may occur in anxiety or depression, linked to serotonin dysregulation or prefrontal inhibition, contrasting with mania’s uninhibited, accelerated verbal output driven by neurochemical overstimulation.

Choice D reason: Psychomotor retardation, slowed speech and movement, is typical of depression, driven by serotonin and dopamine deficits. In acute mania, heightened dopamine and norepinephrine activity cause rapid speech and agitation, making psychomotor retardation incompatible with the neurobiological profile of manic speech patterns.

Choice A reason: One-to-one observation is the priority after a suicide attempt, as the adolescent’s recent action indicates high risk of recurrence due to serotonin dysregulation and prefrontal cortex deficits. Continuous monitoring prevents self-harm by ensuring immediate intervention, addressing the acute neurobiological risk of impulsivity and suicidal ideation in this critical period.

Choice B reason: Encouraging peer interaction supports long-term mental health but is secondary in an acute post-suicide attempt phase. The adolescent’s serotonin imbalances and heightened impulsivity increase self-harm risk, requiring immediate safety measures over social engagement, which could overwhelm or trigger distress in a neurobiologically vulnerable state.

Choice C reason: Attending a support group aids long-term recovery by fostering social connection and coping skills. However, post-suicide attempt, the adolescent’s acute risk, driven by serotonin dysregulation and prefrontal dysfunction, prioritizes safety. Groups may be premature, as emotional instability could exacerbate distress, making observation the immediate need.

Choice D reason: Administering antidepressants addresses underlying depression but takes weeks to affect serotonin levels. Post-suicide attempt, immediate safety is critical due to ongoing impulsivity and neurobiological instability. Observation prevents harm during this high-risk period, making medication secondary until the acute crisis is stabilized.