If the nurse has to clean up a spill of antineoplastic drug, which of the following personal protective equipment should be worn?

Choice A rationale:

Laxatives are generally contraindicated in clients with chronic hepatitis due to potential liver-related complications. However, this choice is not directly related to the use of laxatives.

Choice B rationale:

Laxatives may be used with caution in clients with type 1 diabetes to manage constipation. While there are considerations related to blood sugar control, it is not an absolute contraindication.

Choice D rationale:

Laxatives can be used in clients with cardiac disease, although some types of laxatives may be safer than others. This choice does not represent a contraindication.

Choice A rationale:

Aminoglycosides are known to have nephrotoxic effects. Nephrotoxicity refers to kidney toxicity, and aminoglycosides can cause damage to the renal tubules, leading to impaired kidney function. The nurse should be alert to this potential toxicity when administering these drugs, as it can result in kidney dysfunction, altered serum creatinine levels, and electrolyte imbalances.

Choice B rationale:

Cardiotoxicity is not typically associated with aminoglycosides. These antibiotics primarily affect the kidneys and the inner ear. There is no direct relationship between aminoglycosides and cardiac toxicity.

Choice C rationale:

Hepatotoxicity refers to liver toxicity and is not a common side effect of aminoglycosides. Aminoglycosides are primarily metabolized in the kidneys and are excreted through urine, making kidney toxicity a more significant concern.

Choice D rationale:

Cytotoxicity is a broad term that refers to the toxicity of cells. Aminoglycosides do not typically cause generalized cytotoxic effects in the body. Their primary toxicities are related to specific organ systems, such as the kidneys and the inner ear.