The antagonistic agent to digoxin toxicity is what?
Protamine sulfate.
Acetylcysteine.
Antidigoxin.
Activated charcoal.
The Correct Answer is C
Antidigoxin is an antidote for digoxin toxicity that binds and inactivates digoxin, a cardiac glycoside that can cause life-threatening arrhythmias, hyperkalemia, and other symptoms when overdosed. Antidigoxin is also known as digoxin immune Fab or DIGIFab.
Choice A, protamine sulfate, is wrong because it is an antidote for heparin, an anticoagulant that can cause bleeding when overdosed.
Choice B, acetylcysteine, is wrong because it is an antidote for acetaminophen, a painkiller that can cause liver damage when overdosed.
Choice D, activated charcoal, is wrong because it is a nonspecific adsorbent that can reduce the absorption of some drugs or poisons from the gastrointestinal tract, but it is not effective for digoxin toxicity.
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Related Questions
Correct Answer is A
Explanation
This is because digoxin inhibits the Na-K-ATPase pump on the membrane of cardiac cells, which can cause extracellular potassium levels to rise.Hypokalemia (low potassium) caused by large dosages of diuretics may result in digoxin toxicity even at low serum digoxin levels.Digoxin toxicity can cause gastrointestinal, constitutional, and/or cardiovascular symptoms, as well as ECG changes such as signs of increased automaticity and atrioventricular node blockade.
Choice B is wrong because calcium 9.2 mg/dL is within the normal range of 8.5 to 10.5 mg/dL.Hypercalcemia (high calcium) can increase sensitivity to digoxin effects and lead to toxicity even with a lower concentration of serum digoxin, but this is not the case here.
Choice C is wrong because potassium 4.8 mEq/L is within the normal range of 3.5 to 5.0 mEq/L.
Hyperkalemia (high potassium) can also increase the risk of digoxin toxicity, but this is not the case here.
Choice D is wrong because calcium 10.3 mg/dL is within the normal range of 8.5 to 10.5 mg/dL.Hypercalcemia (high calcium) can increase sensitivity to digoxin effects and lead to toxicity even with a lower concentration of serum digoxin, but this is not the case here.
Correct Answer is C
Explanation
Phenazopyridine hydrochloride (Pyridium) is a urinary tract analgesic that can relieve the pain, burning, and discomfort caused by infection or irritation of the urinary tract.However, it can also cause some side effects, one of which is changing the color of bodily secretions to reddish orange. This is due to the excretion of the drug in the urine, saliva, sweat, and tears.The color change is harmless and usually disappears when the drug is stopped.
Choice A is wrong because phenazopyridine does not change bodily secretions to alkaline.In fact, it may interfere with the urine test that measures acidity (pH) and glucose.
Choice B is wrong because phenazopyridine does not change bodily secretions to pinkish.However, some other drugs, such as rifampin and doxorubicin, may cause urine to turn red or pink.
Choice D is wrong because phenazopyridine does not change bodily secretions to black.However, some other drugs, such as metronidazole and nitrofurantoin, may cause urine to turn brown or dark yellow.
Some other common side effects of phenazopyridine include headache, dizziness, indigestion, and stomach pain.Some serious side effects include skin itching, interference with the oxygen-carrying capacity of red blood cells, hemolytic anemia, and renal and hepatic toxicity.
These problems are more common in people who have existing kidney problems or take more than recommended.If you experience any of these symptoms, stop taking phenazopyridine hydrochloride and talk to a healthcare provider right away.
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