The most significant difference between Acute Lymphocytic Leukemia (ALL) and Acute Myelogenous Leukemia (AML) is:
Cell type affected
Acute Lymphocytic Leukemia (ALL) mostly affects children, and AML affects adults most often.
Clinical manifestations
Diagnostic tests used
The Correct Answer is A
Choice A reason: The primary distinction between ALL and AML is the type of cell that becomes cancerous. Acute Lymphocytic Leukemia (ALL) affects the lymphoid cell line. Lymphoid cells, or lymphocytes, are a type of white blood cell that plays a crucial role in the immune system, helping the body to fight infections. There are three types of lymphocytes: B cells, T cells, and natural killer (NK) cells. In ALL, the malignant transformation of these lymphocytes occurs, leading to an overproduction of immature lymphoid cells, or lymphoblasts. These lymphoblasts crowd out normal blood cells in the bone marrow, leading to symptoms such as anemia, susceptibility to infections, and easy bruising or bleeding.
Choice B reason: While it is true that ALL is more prevalent in children and AML is more common in adults, this age distribution is not the primary distinguishing feature between the two types of leukemia. ALL represents about 75% of pediatric leukemia cases, typically affecting children between 2 and 5 years old, while AML is more commonly diagnosed in adults, with the incidence increasing with age. However, both types can occur at any age, and the age of onset alone is not sufficient to distinguish between them. The differentiation based on cell type remains the most significant factor.
Choice C reason: Clinical manifestations of ALL and AML can be very similar because both involve the proliferation of immature white blood cells in the bone marrow, which disrupts normal blood cell production. Common symptoms include fatigue, frequent infections, fever, weight loss, easy bruising or bleeding, and bone pain. These symptoms result from the overproduction of immature leukemic cells and the subsequent suppression of normal hematopoiesis. Although there may be some differences in presentation based on the specific cell types involved, clinical manifestations are not the primary basis for differentiating between ALL and AML.
Choice D reason: The diagnostic tests used for ALL and AML are quite similar and typically include complete blood counts (CBC), bone marrow biopsy, and flow cytometry to identify the types of cells involved. Cytogenetic and molecular studies are also used to detect specific genetic abnormalities associated with each type of leukemia. While certain markers and genetic mutations may differ between ALL and AML, the overall approach to diagnosis involves similar testing methods. Therefore, the primary difference between the two leukemias lies in the cell type affected rather than the specific diagnostic tests used.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A reason: The neck is the most common site where individuals with Hodgkin Lymphoma (HL) present with nontender enlarged lymph nodes. These lymph nodes are typically firm and rubbery in texture. The cervical lymph nodes are often affected first in HL, making the neck a primary area of concern for this type of lymphoma. Early detection and biopsy of these lymph nodes can help in diagnosing HL.
Choice B reason: While the abdomen can be involved in Hodgkin Lymphoma, it is not the most common initial presentation site. Involvement of the abdominal lymph nodes typically occurs at later stages of the disease. Enlarged lymph nodes in the abdomen can be detected through imaging studies but are less accessible for physical examination compared to those in the neck.
Choice C reason: The kidney is not a typical site for lymph node involvement in Hodgkin Lymphoma. HL primarily affects the lymphatic system, including lymph nodes, spleen, and other lymphoid tissues. Direct involvement of the kidney is rare and usually occurs in advanced stages of the disease.
Choice D reason: The spleen is a lymphoid organ that can be involved in Hodgkin Lymphoma, especially in more advanced stages. However, it is not the primary site where nontender enlarged lymph nodes are first detected. Enlargement of the spleen (splenomegaly) can occur due to the spread of HL, but the initial presentation is usually in the lymph nodes of the neck.
Correct Answer is D
Explanation
Choice A reason: While alcohol consumption is a known risk factor for colon cancer, it is not considered the primary risk factor. Excessive alcohol intake can increase the risk of developing colorectal cancer, but its impact is less significant compared to age.
Choice B reason: Smoking is another risk factor for colon cancer, and long-term tobacco use has been linked to an increased risk of developing colorectal cancer. However, it is not the primary risk factor. Smoking primarily affects the lungs but also has systemic effects that can contribute to various cancers, including colorectal cancer.
Choice C reason: Chronic inflammatory conditions, such as inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, can increase the risk of colon cancer. Chronic inflammation can lead to cellular changes and damage in the colon, which may eventually result in cancer. However, age remains the most significant risk factor.
Choice D reason: Age is the primary risk factor for colon cancer. The risk of developing colorectal cancer increases significantly with age, with the majority of cases occurring in individuals over the age of 50. As people age, the likelihood of genetic mutations and cellular damage accumulates, increasing the risk of cancer development.
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