The most significant difference between Acute Lymphocytic Leukemia (ALL) and Acute Myelogenous Leukemia (AML) is:
Cell type affected
Acute Lymphocytic Leukemia (ALL) mostly affects children, and AML affects adults most often.
Clinical manifestations
Diagnostic tests used
The Correct Answer is A
Choice A reason: The primary distinction between ALL and AML is the type of cell that becomes cancerous. Acute Lymphocytic Leukemia (ALL) affects the lymphoid cell line. Lymphoid cells, or lymphocytes, are a type of white blood cell that plays a crucial role in the immune system, helping the body to fight infections. There are three types of lymphocytes: B cells, T cells, and natural killer (NK) cells. In ALL, the malignant transformation of these lymphocytes occurs, leading to an overproduction of immature lymphoid cells, or lymphoblasts. These lymphoblasts crowd out normal blood cells in the bone marrow, leading to symptoms such as anemia, susceptibility to infections, and easy bruising or bleeding.
Choice B reason: While it is true that ALL is more prevalent in children and AML is more common in adults, this age distribution is not the primary distinguishing feature between the two types of leukemia. ALL represents about 75% of pediatric leukemia cases, typically affecting children between 2 and 5 years old, while AML is more commonly diagnosed in adults, with the incidence increasing with age. However, both types can occur at any age, and the age of onset alone is not sufficient to distinguish between them. The differentiation based on cell type remains the most significant factor.
Choice C reason: Clinical manifestations of ALL and AML can be very similar because both involve the proliferation of immature white blood cells in the bone marrow, which disrupts normal blood cell production. Common symptoms include fatigue, frequent infections, fever, weight loss, easy bruising or bleeding, and bone pain. These symptoms result from the overproduction of immature leukemic cells and the subsequent suppression of normal hematopoiesis. Although there may be some differences in presentation based on the specific cell types involved, clinical manifestations are not the primary basis for differentiating between ALL and AML.
Choice D reason: The diagnostic tests used for ALL and AML are quite similar and typically include complete blood counts (CBC), bone marrow biopsy, and flow cytometry to identify the types of cells involved. Cytogenetic and molecular studies are also used to detect specific genetic abnormalities associated with each type of leukemia. While certain markers and genetic mutations may differ between ALL and AML, the overall approach to diagnosis involves similar testing methods. Therefore, the primary difference between the two leukemias lies in the cell type affected rather than the specific diagnostic tests used.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Choice A reason: Type 1 diabetes is characterized by the destruction of pancreatic islet cells (also known as beta cells) that produce insulin. This autoimmune process leads to a severe lack of insulin in the body. Insulin is essential for regulating blood glucose levels, and without it, glucose cannot enter the cells and remains in the bloodstream, leading to hyperglycemia. This destruction of insulin-producing cells is the fundamental defect in type 1 diabetes.
Choice B reason: Resistance of insulin-sensitive tissues to insulin is a characteristic of type 2 diabetes, not type 1 diabetes. In type 2 diabetes, the body's cells become resistant to insulin, and the pancreas may eventually fail to produce enough insulin to overcome this resistance. This leads to elevated blood glucose levels, but the underlying mechanism is different from the autoimmune destruction seen in type 1 diabetes.
Choice C reason: Stimulation by food intake of glucose production resulting in increased insulin production is not a defining feature of type 1 diabetes. While the intake of food does lead to glucose production and a subsequent need for insulin, this mechanism is part of normal physiology and is not specific to any type of diabetes. Type 1 diabetes specifically involves the lack of insulin production due to the destruction of the pancreatic beta cells.
Choice D reason: Decreased production of releasing hormones by the hypothalamus is not related to the pathophysiology of type 1 diabetes. The hypothalamus plays a role in regulating various hormonal processes, but type 1 diabetes is primarily an autoimmune disorder affecting the pancreas. The destruction of insulin-producing beta cells in the pancreas is the key issue in type 1 diabetes.
Correct Answer is ["A","B","D"]
Explanation
Choice A reason: Gestational diabetes is indeed due to insulin resistance. During pregnancy, hormonal changes can cause the body's cells to become less responsive to insulin, leading to higher blood glucose levels.
Choice B reason: In gestational diabetes, the pancreas is unable to produce enough insulin to overcome the insulin resistance caused by pregnancy hormones. This insufficient insulin production leads to elevated blood glucose levels.
Choice C reason: Gestational diabetes is not permanent. It specifically occurs during pregnancy and usually resolves after the baby is born. However, women who have had gestational diabetes are at an increased risk of developing type 2 diabetes later in life.
Choice D reason: Gestational diabetes occurs during pregnancy. It is diagnosed when blood glucose levels are elevated in a pregnant woman who did not have diabetes before pregnancy.
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