The nurse is preparing to administer a unit of packed red blood cells (PRBC's) to a patient whose blood type is A- (negative). The nurse knows that this patient can receive transfusions from which blood types? (SELECT ALL THAT APPLY).

A) Single color throughout:
A mole that is a single, consistent color is typically not a concern for melanoma. However, one of the key warning signs of melanoma is a mole that has multiple colors or shades, such as tan, brown, black, or even red or blue. The presence of more than one color in a mole can indicate melanoma, and the client should be advised to seek medical attention if the mole has varied colors.

B) Diameter smaller than 2mm:
A mole that is smaller than 2mm in diameter is typically not a concern for melanoma. Melanomas are often larger than 6mm in diameter, about the size of a pencil eraser, though smaller melanomas can also occur. A mole smaller than 2mm is usually considered benign, but any change in size, shape, or color, regardless of the starting size, should be evaluated.

C) Has uneven or irregular borders:
One of the primary warning signs of melanoma is the presence of irregular or uneven borders on a mole. Normal moles typically have smooth, even borders, while moles with jagged, blurred, or irregular edges are more likely to be melanoma. The client should seek medical attention if they notice any moles with irregular borders, as this could be a sign of malignancy.

D) Is symmetrical in shape:
A mole that is symmetrical (both halves are the same size and shape) is generally not a concern for melanoma. In contrast, asymmetry (when one half of the mole does not match the other half) is a key warning sign for melanoma. A mole that lacks symmetry should be evaluated by a healthcare provider.

A) Treatment plan will need to be changed to achieve the desired effect:
The decrease in the carcinoembryonic antigen (CEA) levels from 50 ng/mL to 10 ng/mL suggests that the cancer is responding to the current treatment, not that the treatment plan needs to be changed. A drop in CEA levels typically indicates a positive response to treatment, such as chemotherapy, in reducing the number or size of cancer cells.

B) Cancer treatment is having the desired effect on killing cancer cells:
Carcinoembryonic antigen (CEA) is a tumor marker that is often elevated in individuals with certain cancers, particularly colorectal cancer. A decrease in CEA levels, as noted in this case (from 50 ng/mL to 10 ng/mL), usually signifies that the treatment is successfully targeting the cancer and reducing the tumor burden. This drop suggests that the chemotherapy is effectively killing cancer cells and reducing the size or activity of the tumor.

C) Client is at greater risk for tumor lysis syndrome:
Tumor lysis syndrome typically occurs when large numbers of cancer cells die rapidly, releasing their intracellular contents into the bloodstream, which can lead to metabolic disturbances like hyperkalemia, hyperphosphatemia, and renal failure. It is more common in aggressive hematologic cancers, such as leukemia or lymphoma, and typically presents with a rapid rise in tumor marker levels, not a decrease.

D) Cancer has increased size and metastatic sites:
An increase in tumor size or the development of metastatic sites would typically result in an increase in CEA levels, not a decrease. Since CEA levels have dropped, it is more likely that the cancer is shrinking or responding to the current treatment. This finding is more indicative of a positive response rather than disease progression.