The nurse is preparing to administer medications to a 54-year old client. Which medications taken would be affected by the first-pass effect? (Select All that Apply.)
Nitroglycerin 10mg Sublingual Tablet
Morphine 2mg IV (Intravenously)
Famotidine 10mg Tablet
Nitroglycerin 4mg Sublingual Tablet
Acetaminophen 325mg Capsule
Diphenhydramine (Benadryl) 25mg Tablet
Correct Answer : C,E,F
A. Nitroglycerin 10mg Sublingual Tablet:
Nitroglycerin taken sublingually (under the tongue) bypasses the gastrointestinal tract and the liver’s first-pass metabolism. It is designed to act quickly and directly enter the bloodstream through the mucous membranes, avoiding significant first-pass effect.
B. Morphine 2mg IV (Intravenously):
Morphine administered intravenously bypasses the gastrointestinal tract and liver, thus avoiding the first-pass effect entirely. The drug directly enters systemic circulation, providing immediate effect.
C. Famotidine 10mg Tablet:
Famotidine, when taken orally, undergoes significant first-pass metabolism. This means that a portion of the drug is metabolized by the liver before it reaches systemic circulation, affecting its bioavailability.
D. Nitroglycerin 4mg Sublingual Tablet:
Similar to the 10mg sublingual tablet, nitroglycerin administered sublingually bypasses the first-pass effect. The medication enters the bloodstream directly through the mucous membranes in the mouth.
E. Acetaminophen 325mg Capsule:
Acetaminophen, when taken orally, undergoes first-pass metabolism. A significant portion of the drug is metabolized in the liver before reaching systemic circulation, which can impact its overall effectiveness.
F. Diphenhydramine (Benadryl) 25mg Tablet:
Diphenhydramine, taken orally, is also affected by the first-pass effect. As with other oral medications, a part of the drug is metabolized by the liver before reaching systemic circulation, which can affect its efficacy and bioavailability.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is {"A":{"answers":"C"},"B":{"answers":"D"},"C":{"answers":"A"},"D":{"answers":"B"}}
Explanation
Naloxone is an opioid antagonist and is used to reverse opioid overdoses.
Flumazenil is a benzodiazepine antagonist and can reverse the effects of benzodiazepines.
Glucagon can be used to treat beta-blocker overdose by increasing heart rate and blood pressure.
Acetylcysteine acts as an antidote for acetaminophen toxicity by replenishing glutathione levels to enhance non-toxic metabolism of acetaminophen.
Correct Answer is D
Explanation
A. Chemical name:
The chemical name of a drug refers to its molecular structure and is often complex and technical, such as "2-(4-isobutylphenyl)propionic acid" for ibuprofen. This name is used primarily by chemists and is not typically used in clinical settings.
B. Generic name:
The generic name of a drug is its non-proprietary name, which is often simpler than the chemical name and is used universally to identify the drug regardless of the brand. For ibuprofen, the generic name is "ibuprofen." It is distinct from the brand name, which is a trademarked name used by manufacturers.
C. Nonproprietary name:
The term "nonproprietary name" is synonymous with the generic name. It refers to the drug's official, universally accepted name that is not associated with any specific brand. In this case, "ibuprofen" is the nonproprietary or generic name.
D. Brand name:
The brand name, also known as the trade name, is the name given by the manufacturer and is protected by trademark. "Motrin" is the brand name for ibuprofen. It is used in marketing and prescribing to differentiate it from other brands or generic forms of the same medication.
Whether you are a student looking to ace your exams or a practicing nurse seeking to enhance your expertise , our nursing education contents will empower you with the confidence and competence to make a difference in the lives of patients and become a respected leader in the healthcare field.
Visit Naxlex, invest in your future and unlock endless possibilities with our unparalleled nursing education contents today
Report Wrong Answer on the Current Question
Do you disagree with the answer? If yes, what is your expected answer? Explain.
Kindly be descriptive with the issue you are facing.