The healthcare provider orders Ceftriaxone 20 mg IV every 6 hours. The instructions say to reconstitute 10 mg of Ceftriaxone with 6.5 ml of normal saline for a final concentration of 5 mg/ml. How many mL would the nurse administer? (Round to the nearest tenth)

A. Absorption:
Chronic liver failure primarily affects the metabolism of drugs rather than their absorption. While liver disease can impact various bodily functions, the absorption of medications is generally more influenced by gastrointestinal factors and not as directly affected by liver function.

B. Excretion:
Excretion of drugs is primarily managed by the kidneys, not the liver. While liver failure can lead to changes in drug metabolism, it does not directly impair the excretion process, which is largely renal. However, compromised liver function can indirectly affect renal excretion due to altered pharmacokinetics.

C. Metabolism:
Liver failure significantly affects drug metabolism. The liver is the primary site for the metabolism of many medications, converting drugs into more water-soluble compounds for excretion. In chronic liver failure, the liver's ability to metabolize drugs is impaired, leading to potential drug accumulation and increased risk of toxicity. This step of pharmacokinetics is most directly impacted by liver dysfunction.

D. Distribution:
While liver function can affect drug distribution to some extent, it is not as directly impacted as metabolism. Distribution can be influenced by factors such as changes in plasma protein levels and blood flow, but the liver's primary role in drug metabolism is more directly affected by chronic liver failure.

A) Does not have an effect: Food can significantly affect drug dissolution and absorption, so it is not accurate to say it has no effect. The presence of food in the gastrointestinal tract can alter how drugs are absorbed.

B) Increases: While food can sometimes increase the absorption of certain medications by stimulating digestive processes, it generally does not increase drug absorption for all medications. In many cases, food can delay or decrease the rate of drug absorption.

C) Decreases: Food commonly decreases the rate and extent of drug absorption. This can occur because food may bind to the drug, alter the pH of the stomach, or affect gastric emptying, leading to reduced drug dissolution and absorption.

D) Enhances: Food generally does not enhance drug dissolution and absorption for most medications. While some medications are better absorbed with food, in many cases, food can reduce the rate at which a drug is absorbed, leading to decreased efficacy.