The practical nurse (PN) administers filgrastim subcutaneous to a client with neutropenia. The client becomes troubled with bone pain. Which action should the PN take?

Choice A reason: Eating aged cheeses, high in tyramine, is relevant for monoamine oxidase inhibitors, not TCAs, which do not interact with tyramine. This dietary habit does not affect TCA-related sleep disturbances, making it irrelevant for addressing the client’s early morning awakening.

Choice B reason: Taking a warm bath at night may promote relaxation but does not directly address TCA-related sleep issues. While helpful for general sleep hygiene, it is less critical than medication timing, which directly influences TCA’s stimulatory effects on sleep patterns.

Choice C reason: Dry mouth is a common TCA side effect due to anticholinergic properties but is not directly linked to sleep disturbances. It may cause discomfort but does not explain or address early morning awakening, making this information less relevant for sleep improvement.

Choice D reason: Taking TCAs upon rising can cause insomnia, as their stimulatory effects peak during sleep hours. TCAs increase norepinephrine, disrupting sleep architecture. Adjusting to bedtime dosing may reduce early morning awakening, making this information critical for optimizing sleep and therapeutic outcomes.

Choice A reason: Ankle circumference monitors edema, which mannitol reduces by drawing fluid from tissues. However, this is secondary to urinary output, as mannitol’s primary action is diuresis, increasing urine production to reduce intracranial or intraocular pressure, making edema measurement less critical.

Choice B reason: Heart rate is relevant for overall monitoring but not the primary outcome for mannitol, which acts as an osmotic diuretic. Cardiovascular effects are secondary, and mannitol’s efficacy is better assessed by urine output, which directly reflects its diuretic mechanism.

Choice C reason: Dietary intake is unrelated to mannitol’s therapeutic effect. Mannitol pulls fluid into the bloodstream, increasing urine output, not influenced by diet. Monitoring intake may be relevant for other conditions, but it is not critical for assessing mannitol’s diuretic action.

Choice D reason: Urinary output is the most important outcome, as mannitol, an osmotic diuretic, increases urine production by drawing fluid into the renal tubules, reducing intracranial or intraocular pressure. Adequate output (e.g., >30 mL/hour) confirms efficacy, preventing fluid overload or renal complications.