What factor has the most impact on the pharmacokinetic phase of distribution?

Low albumin

Renal disease

Hepatic disease

An elevated gastric pH

Answer and Explanation

The Correct Answer is A

A) Low albumin: This factor has the most impact on the pharmacokinetic phase of distribution. Albumin is a key protein in the blood that binds to many medications. When albumin levels are low, fewer drug molecules will be bound, leading to an increased concentration of free (unbound) drug in the bloodstream. This can result in enhanced drug effects or toxicity, as the unbound drug is pharmacologically active and more readily able to cross cell membranes.

B) Renal disease: While renal disease can impact drug elimination and excretion, it does not have as direct an effect on the distribution phase of pharmacokinetics. Renal function primarily affects the clearance of drugs from the body rather than how the drug is distributed within the tissues.

C) Hepatic disease: Hepatic disease can affect the metabolism of drugs and their clearance, but it does not directly affect the distribution phase. While the liver is involved in metabolizing drugs, it is the ability to clear or process the drug that is most influenced, rather than its distribution to tissues.

D) An elevated gastric pH: Elevated gastric pH (which can occur with antacid use or in certain conditions) can affect the absorption of some medications but has minimal direct impact on the distribution phase of pharmacokinetics. Distribution is primarily concerned with how a drug moves from the bloodstream into tissues, and this is more influenced by factors like blood flow, protein binding, and the drug's lipophilicity, rather than the pH of the stomach.

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Correct Answer is B

Explanation

This action reflects the planning phase of the nursing process, where the nurse sets measurable and achievable goals based on the client's assessment data.

Here’s how the other options fall into different phases:

A. Demonstrating how to perform a blood glucose test = Implementation (teaching/intervention).

C. Administering insulin = Implementation (carrying out an intervention).

D. Checking blood glucose level = Assessment (gathering data).

A. Failed communication B. Dose miscalculation C. Lack of client education D. Poor distribution practices

Correct Answer is B

Explanation

A) Failed communication: While communication errors can lead to medication mistakes, in this specific scenario, there is no mention of poor communication. The prescription is clear, and the issue is more likely related to the accuracy of the prescribed dose or the nurse’s understanding of it, making "failed communication" a less likely source of error in this case.

B) Dose miscalculation: This is the most likely source of potential error. The medication is ordered as 0.9 mg of ondansetron IV, which is an unusual dosage because the typical dose of ondansetron IV for nausea is usually 4 mg or 8 mg. A dose of 0.9 mg is very specific and could easily be miscalculated, especially if the nurse is not familiar with this specific dosage form or if there’s any confusion regarding the intended dose. This could lead to an error either in preparation or administration of the medication.

C) Lack of client education: While client education is important for many aspects of treatment, it’s not directly related to the potential medication error in this scenario. The nurse’s concern should focus on the accuracy of administering the prescribed dose correctly, not the client’s understanding of the medication.

D) Poor distribution practices: Poor distribution practices may affect the availability or storage of medications, but this is not the likely source of error in this case. The concern here is more about the correct dosage and potential for miscalculation, rather than issues related to drug distribution or storage.

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Laboratory Test	Result	Normal Range
Sodium	146 mEq/dL	135-145 mEq/L
Calcium	8.2 mg/dL	8.4-10.2 mg/dL
Magnesium	1.2 mg/dL	1.6-2.2 mg/dL
Gastric pH	6	1-4

What factor has the most impact on the pharmacokinetic phase of distribution?

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Naxlex Comprehensive Predictor Exams

A nurse assesses the client and determines the client is at risk for unstable blood glucose. Which activity best reflects the planning phase of the nursing process?

Correct Answer is B

Explanation

A client is ordered .9mg ondansetron, IV, PRN q6 hours for nausea. The nurse anticipates which of the following sources to cause potential medication error?

Correct Answer is B

Explanation

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