What is the underlying pathophysiology of Paget's disease?
Decreased bone density due to calcium deficiency.
Increased bone turnover and disordered bone remodeling.
Excessive collagen production leading to bone deformities.
Autoimmune attack on osteoblasts causing bone destruction.
The Correct Answer is B
The underlying pathophysiology of Paget's disease involves increased bone turnover and disordered bone remodeling. Osteoclasts, the bone-resorbing cells, become overactive, leading to excessive bone resorption. Osteoblasts, the bone-forming cells, attempt to repair the resorbed bone, but their activity is disordered, resulting in the formation of structurally abnormal bone.
a. Decreased bone density due to calcium deficiency: This is the pathophysiology of osteoporosis, not Paget's disease. In Paget's disease, bone density can be normal or increased due to the disordered bone remodeling.
c. Excessive collagen production leading to bone deformities: Excessive collagen production is not a characteristic feature of Paget's disease. The condition primarily involves abnormal bone remodeling by osteoclasts and osteoblasts.
d. Autoimmune attack on osteoblasts causing bone destruction: Paget's disease is not an autoimmune disorder. The disease is characterized by increased bone resorption and disordered bone formation, not an immune-mediated attack on osteoblasts.
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Related Questions
Correct Answer is D
Explanation
Enlarged frontal bossing (prominent forehead) is a cranial finding often seen in clients with Paget's disease due to increased bone growth in the skull bones. This can cause pressure and contribute to headaches.
a. Nystagmus: Nystagmus is an involuntary, rhythmic movement of the eyes and is not directly associated with Paget's disease.
b. Diplopia: Diplopia, or double vision, is not a typical finding in Paget's disease. It may be related to other neurological or ocular conditions.
c. Papilledema: Papilledema is swelling of the optic disc due to increased intracranial pressure. While headaches can be associated with Paget's disease, papilledema is not a common manifestation of the condition.
Correct Answer is A
Explanation
Regular follow-up appointments with the healthcare provider are essential for clients with Paget's disease to monitor for potential complications and disease progression. Periodic evaluations help assess bone health, check for bone deformities, and adjust the treatment plan if necessary.
b. To obtain prescriptions for pain medications: While pain management may be addressed during follow-up appointments, it is not the primary reason for regular visits. Pain medications can be prescribed as needed.
c. To receive physical therapy for bone pain: Physical therapy may be part of the treatment plan for managing bone pain, but it does not solely warrant regular follow-up appointments.
d. To assess calcium and vitamin D levels: Calcium and vitamin D levels may be assessed, but they are not the main focus of regular follow-up appointments. The primary purpose is to monitor the condition's progression and assess for potential complications.
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