What is the underlying pathophysiology of Paget's disease?
Decreased bone density due to calcium deficiency.
Increased bone turnover and disordered bone remodeling.
Excessive collagen production leading to bone deformities.
Autoimmune attack on osteoblasts causing bone destruction.
The Correct Answer is B
The underlying pathophysiology of Paget's disease involves increased bone turnover and disordered bone remodeling. Osteoclasts, the bone-resorbing cells, become overactive, leading to excessive bone resorption. Osteoblasts, the bone-forming cells, attempt to repair the resorbed bone, but their activity is disordered, resulting in the formation of structurally abnormal bone.
a. Decreased bone density due to calcium deficiency: This is the pathophysiology of osteoporosis, not Paget's disease. In Paget's disease, bone density can be normal or increased due to the disordered bone remodeling.
c. Excessive collagen production leading to bone deformities: Excessive collagen production is not a characteristic feature of Paget's disease. The condition primarily involves abnormal bone remodeling by osteoclasts and osteoblasts.
d. Autoimmune attack on osteoblasts causing bone destruction: Paget's disease is not an autoimmune disorder. The disease is characterized by increased bone resorption and disordered bone formation, not an immune-mediated attack on osteoblasts.
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Related Questions
Correct Answer is B
Explanation
Calcium and vitamin D help reduce the risk of bone fractures in Paget's disease.
Explanation: Adequate calcium and vitamin D intake are essential for maintaining bone health and reducing the risk of bone fractures, especially in individuals with Paget's disease. While these nutrients do not cure Paget's disease, they play a crucial role in supporting bone strength and density.
a. Calcium and vitamin D can prevent the development of Paget's disease: This statement is incorrect. Paget's disease is primarily a result of genetic factors, and calcium and vitamin D intake do not prevent its development.
c. Calcium and vitamin D can cure Paget's disease: This statement is incorrect. While calcium and vitamin D are important for bone health, they do not cure Paget's disease. Treatment usually involves medications to manage the condition.
d. Calcium and vitamin D decrease bone turnover in Paget's disease: This statement is not entirely accurate. Calcium and vitamin D do not directly decrease bone turnover in Paget's disease. Medications like bisphosphonates are prescribed to address bone remodeling.
Correct Answer is A
Explanation
X-rays are the most useful imaging modality for assessing the extent and severity of bone involvement in Paget's disease. X-rays can reveal the characteristic bony overgrowth and thickening, as well as any bone deformities and fractures.
b. Computed tomography (CT) scan: CT scans can provide detailed images of bones and soft tissues, but they may not be the initial choice for evaluating Paget's disease. X-rays are more specific for the condition.
c. Magnetic resonance imaging (MRI): While an MRI can provide detailed images of bones and soft tissues, it may not be the first-line imaging choice for evaluating Paget's disease. X-rays are more specific for bone involvement.
d. Bone densitometry (DXA scan): Bone densitometry is used to assess bone mineral density and is commonly used for conditions like osteoporosis. It may not provide the necessary information for evaluating Paget's disease.
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