When administering medications to a group of clients, which client should the nurse closely monitor for development of acute kidney injury (AKI)?

Choice B reason: Vancomycin is an antibiotic that can treat serious bacterial infections that are resistant to other antibiotics. However, vancomycin can also cause nephrotoxicity, or damage to the kidneys, especially when given in high doses or for prolonged periods. Nephrotoxicity can lead to AKI, which is a sudden and severe decrease in kidney function that can cause fluid and electrolyte imbalances, acid-base disorders, uremia, and death. Therefore, the nurse should closely monitor the client who is receiving vancomycin for development of AKI by checking their serum creatinine and blood urea nitrogen (BUN) levels, urine output and specific gravity, and signs and symptoms of fluid overload or dehydration.

Choice A reason: Sucralfate is an anti-ulcer drug that forms a protective coating over the stomach lining and prevents further damage from acid or pepsin. Sucralfate does not cause nephrotoxicity or AKI and has minimal systemic absorption or side effects. Therefore, the nurse does not need to closely monitor the client who is taking sucralfate for development of AKI.

Choice C reason: Lorazepam is a benzodiazepine that can treat anxiety, insomnia, seizures, or alcohol withdrawal. Lorazepam does not cause nephrotoxicity or AKI and has low renal clearance or elimination. Therefore, the nurse does not need to closely monitor the client who is taking lorazepam for development of AKI.

Choice D reason: Digoxin is a cardiac glycoside that can treat heart failure or atrial fibrillation by increasing the force and efficiency of heart contractions and slowing down the heart rate. Digoxin does not cause nephrotoxicity

Choice A reason: Diarrhea is a common side effect of metoclopramide, but it is not life-threatening or indicative of a serious reaction. The nurse should monitor the client's fluid and electrolyte status and provide supportive care.

Choice B reason: Involuntary movements, such as twitching, grimacing, or spasms, are signs of a rare but serious condition called tardive dyskinesia, which can be caused by metoclopramide. This condition can be irreversible and disabling, so the nurse should report it immediately and stop the medication.

Choice C reason: Nausea is the reason why the client is receiving metoclopramide, which is an antiemetic drug. If the client still experiences nausea, the nurse should assess the effectiveness of the medication and notify the prescriber if needed.

Choice D reason: Unusual irritability is not a common or serious side effect of metoclopramide. It may be related to other factors, such as stress, pain, or fatigue. The nurse should provide emotional support and reassurance to the client.