When administering zidovudine to a patient with human immunodeficiency virus (HIV), which action should be the first priority for the nurse?

Choice A rationale:

Increased respirations are not a specific symptom of increased intracranial pressure (ICP). They might occur due to other respiratory or metabolic issues.

Choice B rationale:

Widened pulse pressure (the difference between systolic and diastolic blood pressure) is a sign of increased ICP. It results from increased systolic pressure due to the body's attempt to compensate for the rising pressure within the skull.

Choice C rationale:

Prolonged capillary refill is indicative of decreased peripheral perfusion or shock, which can be caused by various factors but is not directly related to ICP.

Choice D rationale:

Decreased blood pressure is not a consistent symptom of increased ICP. In fact, widened pulse pressure is more characteristic.

Choice A rationale:

Painful joints are not a common side effect of prednisone. Prednisone can cause musculoskeletal issues, but painful joints are not a prominent manifestation.

Choice B rationale:

A decrease in appetite is a possible side effect of prednisone. However, it's not the focus of this question, as other choices are more relevant.

Choice C rationale:

A yellow tinge to the whites of the eyes (jaundice) is not a commonly associated side effect of prednisone. Jaundice is usually linked to liver dysfunction or other conditions affecting bilirubin metabolism.

Choice D rationale:

A round face, often referred to as "moon face,”. is a well-recognized side effect of prednisone. It occurs due to fluid retention and fat redistribution, leading to a characteristic facial appearance.