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Where do enteric coated tablets typically disintegrate in the body?

A.

Esophagus

B.

Duodenum

C.

Stomach

D.

Colon

Answer and Explanation

The Correct Answer is B

A) Esophagus
Enteric-coated tablets are designed to not dissolve or disintegrate in the esophagus. They are coated with a protective layer that prevents the tablet from breaking down in the acidic environment of the stomach. This is to ensure that the medication is released in the part of the digestive tract where it is most needed, typically beyond the stomach.

 

B) Duodenum
Enteric-coated tablets are designed to disintegrate in the duodenum, which is the first part of the small intestine. The coating protects the tablet from stomach acid, allowing it to pass intact through the stomach and into the small intestine, where the pH is higher and the coating dissolves, releasing the medication for absorption.

 

C) Stomach
Enteric-coated tablets are specifically designed not to disintegrate in the stomach because the stomach's acidic environment could either damage the drug or cause premature release. The coating ensures that the drug is protected until it reaches the more neutral pH of the duodenum.

 

D) Colon
The colon is too far along in the digestive tract for enteric-coated tablets to typically disintegrate. The design of enteric coatings is intended to protect the drug until it reaches the duodenum, where absorption is most efficient. Enteric coatings are not meant to disintegrate in the colon.


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Related Questions

Correct Answer is C

Explanation

Let's calculate the dosage using the provided information.

Information from the label:

Bumetanide concentration: 0.25 mg/mL

Available volume: 10 mL vial

Order: Bumex (bumetanide) 1 mg IV daily

Calculation:

Determine the desired dose: 1 mg

Use the formula:

Desired dose (mg) / Available concentration (mg/mL) = Volume to administer (mL)

Substitute the values:

1 mg / 0.25 mg/mL = Volume to administer (mL)

Calculate:

Volume to administer = 4 mL

Therefore, the correct answer is C. 4 mL

Correct Answer is D

Explanation

Identify the desired dose and the available concentration:

Desired dose: 5 mg of hydrocodone

Available concentration: 7.5 mg of hydrocodone in 15 mL of elixir

Calculate the volume needed for the desired dose using the formula:

Volume(mL)=(Desireddose(mg)/Availableconcentration(mg/mL))

Determine the available concentration in mg/mL:

Availableconcentration=(7.5mg/15mL)=0.5mg/mL

Calculate the volume needed for a 5 mg dose:

Volume(mL)=(5mg/0.5mg/mL)=10mL

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