Which modes of transmission occur with HIV infection? (Select all that apply)

Choice A reason:
HIV can be transmitted through blood products. This mode of transmission occurs when contaminated blood, used in transfusions or other medical procedures, carries the virus to another person. It is one of the primary ways HIV spreads, especially before strict blood screening protocols were implemented.
Choice B reason:
Perinatal transmission refers to the transmission of HIV from a mother to her fetus during pregnancy, childbirth, or breastfeeding. This is a significant mode of transmission, particularly in regions with high HIV prevalence and limited access to antiretroviral therapy.
Choice C reason:
This choice is incorrect because HIV is not transmitted through airborne means. Unlike respiratory viruses, HIV requires direct contact with certain body fluids for transmission. Airborne transmission would imply that the virus could spread through the air, which is not the case with HIV.
Choice D reason:
Sexual transmission is a major route for HIV spread. The virus is present in bodily fluids such as semen, vaginal fluids, and rectal fluids. Unprotected sexual contact allows the virus to pass from one person to another, making this a crucial mode of HIV transmission.

Choice A reason:
Vitamin K (phytonadione) is the antidote for warfarin overdose. It works by promoting the synthesis of clotting factors that are inhibited by warfarin, thereby reversing the anticoagulant effects. In cases of excessive warfarin intake, administering vitamin K helps restore normal clotting function.

Choice B reason:
Protamine sulfate is the antidote for heparin overdose, not warfarin. It works by neutralizing the anticoagulant effects of heparin, but it has no effect on warfarin-induced anticoagulation. Therefore, it is not appropriate for this situation.

Choice C reason:
A PTT lab test measures the effectiveness of the intrinsic pathway of coagulation and is primarily used to monitor heparin therapy. It is not relevant for managing warfarin overdose, as warfarin affects the extrinsic pathway, which is measured by the PT/INR test.

Choice D reason:
While an INR lab test is essential for monitoring the therapeutic levels of warfarin, the immediate need in this situation is to reverse the effects of the overdose. Administering vitamin K is the necessary intervention to counteract the excessive anticoagulation caused by warfarin.