Which of the following accurately describe the differences between vaso-occlusive crisis, sequestration crisis, and aplastic crisis in sickle cell anemia? (Select All that Apply.)

Aplastic crisis is caused by a decrease in the production of red blood cells in the bone marrow.

Sequestration crisis involves the blockage of small blood vessels by sickled red blood cells.

Vaso-occlusive crisis is characterized by the pooling of large amounts of blood in the spleen and liver.

Aplastic crisis is characterized by the pooling of large amounts of blood in the spleen and liver.

Sequestration crisis is characterized by the pooling of large amounts of blood in the spleen and liver.

Vaso-occlusive crisis involves the blockage of small blood vessels by sickled red blood cells.

Answer and Explanation

Correct Answer : A,E,F

A. Aplastic crisis is caused by a decrease in the production of red blood cells in the bone marrow is correct. Aplastic crisis is often triggered by an infection (such as parvovirus B19), leading to a sudden reduction in red blood cell production, which can exacerbate anemia.

B. Sequestration crisis involves the blockage of small blood vessels by sickled red blood cells is incorrect. This describes a vaso-occlusive crisis, not sequestration crisis. Sequestration crisis involves pooling of blood in the spleen or liver, leading to organ enlargement and circulatory collapse.

C. Vaso-occlusive crisis is characterized by the pooling of large amounts of blood in the spleen and liver is incorrect. Vaso-occlusive crisis is characterized by the blockage of small blood vessels by sickled cells, leading to pain, ischemia, and tissue damage.

D. Aplastic crisis is characterized by the pooling of large amounts of blood in the spleen and liver is incorrect. Aplastic crisis is primarily related to bone marrow failure and reduced red blood cell production, not blood pooling in organs.

E. Sequestration crisis is characterized by the pooling of large amounts of blood in the spleen and liver is correct. In sequestration crisis, the spleen and liver trap large amounts of blood, which can lead to hypovolemic shock and severe anemia.

F. Vaso-occlusive crisis involves the blockage of small blood vessels by sickled red blood cells is correct. Vaso-occlusive crisis occurs when sickled red blood cells obstruct blood flow in small vessels, causing pain, tissue damage, and potential organ dysfunction.

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Correct Answer is ["A","B","C","E","F"]

Explanation

A. Neurological assessment is critical in identifying potential complications, especially in cases of head injury, infection, or brain-related conditions. A change in mental status or neurological findings (e.g., confusion, loss of consciousness) warrants immediate follow-up.

B. Basic metabolic panel provides key information on electrolyte imbalances, kidney function, and acid-base status. Imbalances or abnormalities, such as hyperkalemia or hyponatremia, can indicate life-threatening conditions.

C. Blood pressure/heart rate is crucial to monitor because abnormalities in these vital signs can indicate cardiovascular instability, shock, or autonomic dysfunction. Significant changes require immediate intervention.

D. Abdominal assessment is important but not always immediately urgent unless signs of acute abdominal issues (e.g., severe pain, distention, or bleeding) are present.

E. Complete blood count is essential for monitoring for signs of infection, anemia, or bleeding disorders. Abnormalities such as low hemoglobin or a high white blood cell count require further investigation.

F. Pain assessment is important but may not always indicate an immediate life-threatening issue. However, uncontrolled pain or new-onset severe pain can signal a complication, such as infection or tissue damage, which needs prompt attention.

A. Urine specific gravity 1.015 B. Respiratory rate 24/min C. Heart rate 130/min D. Capillary refill greater than 3 seconds

Correct Answer is A

Explanation

A. Urine specific gravity 1.015 is correct. A specific gravity of 1.015 indicates good hydration status and that the child is effectively retaining fluids after oral rehydration therapy. Normal urine specific gravity ranges from 1.010 to 1.020.

B. Respiratory rate 24/min is not directly related to hydration status and does not necessarily indicate that rehydration therapy has been effective. It is a normal rate for a 3-year-old child, but respiratory rate alone isn't an indicator of fluid balance.

C. Heart rate 130/min is elevated for a 3-year-old child and may indicate dehydration or other stressors, suggesting that oral rehydration therapy has not been completely effective. A normal heart rate for this age is typically 80-120 beats per minute.

D. Capillary refill greater than 3 seconds is a sign of dehydration and poor perfusion, indicating that the oral rehydration therapy has not been effective in restoring hydration. Normal capillary refill time is less than 2 seconds.

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Which of the following accurately describe the differences between vaso-occlusive crisis, sequestration crisis, and aplastic crisis in sickle cell anemia? (Select All that Apply.)

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