Which of the following bones is often affected in Paget's disease?
Humerus (arm bone)
Radius (forearm bone)
Femur (thigh bone)
Fibula (lower leg bone)
The Correct Answer is C
The femur, which is the thigh bone, is often affected in Paget's disease. The condition commonly involves the axial skeleton, such as the skull, spine, and pelvis, as well as the long bones like the femur.
a. Humerus (arm bone): The humerus can be affected in Paget's disease, but it is not as commonly involved as the femur.
b. Radius (forearm bone): The radius can be affected in Paget's disease, but it is not as commonly involved as the femur.
d. Fibula (lower leg bone): The fibula can be affected in Paget's disease, but it is not as commonly involved as the femur.
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Correct Answer is D
Explanation
The most common clinical manifestation of Paget's disease is bone pain and deformities due to abnormal bone remodeling and increased bone turnover.
a. Severe joint pain: While joint pain can occur in Paget's disease due to bone involvement, it is not the most common manifestation. Bone pain and deformities are more characteristic.
b. Unexplained weight loss: Unexplained weight loss is not a typical symptom of Paget's disease. It is not directly related to the bone disorder.
c. Visual disturbances: Visual disturbances are not associated with Paget's disease. This condition primarily affects bones, not the eyes or vision.
Correct Answer is A
Explanation
X-rays are the most useful imaging modality for assessing the extent and severity of bone involvement in Paget's disease. X-rays can reveal the characteristic bony overgrowth and thickening, as well as any bone deformities and fractures.
b. Computed tomography (CT) scan: CT scans can provide detailed images of bones and soft tissues, but they may not be the initial choice for evaluating Paget's disease. X-rays are more specific for the condition.
c. Magnetic resonance imaging (MRI): While an MRI can provide detailed images of bones and soft tissues, it may not be the first-line imaging choice for evaluating Paget's disease. X-rays are more specific for bone involvement.
d. Bone densitometry (DXA scan): Bone densitometry is used to assess bone mineral density and is commonly used for conditions like osteoporosis. It may not provide the necessary information for evaluating Paget's disease.
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