Paget's disease can lead to an increased risk of which complication?

Osteoclasts are the primary cell type responsible for bone resorption in Paget's disease. These cells become overactive, leading to excessive bone breakdown, which is a hallmark of the condition.

a. Osteocytes: Osteocytes are mature bone cells embedded in the bone matrix. While they play a role in maintaining bone health, they are not directly responsible for bone resorption.

b. Osteoblasts: Osteoblasts are bone-forming cells. In Paget's disease, they attempt to repair the resorbed bone but their activity is disordered, leading to structurally abnormal bone formation.

d. Osteoprogenitor cells: Osteoprogenitor cells are undifferentiated cells that can differentiate into osteoblasts. They are not directly involved in the increased bone resorption seen in Paget's disease.

The goal of treatment for Paget's disease is to relieve pain and prevent complications associated with bone deformities and fractures. There is no cure for Paget's disease, but treatment aims to manage symptoms and reduce the risk of complications.
a. Cure the disease completely: Paget's disease is a chronic condition with no known cure. Treatment focuses on symptom management and preventing complications.
c. Restore normal bone density: While treatment may aim to reduce abnormal bone remodeling, restoring normal bone density is not typically achievable. The focus is on pain relief and preventing complications.
d. Regenerate damaged bones: While treatment may improve bone health and reduce deformities, regenerating damaged bones to their original state is not feasible. Treatment aims to manage the disease and its consequences effectively.