Which of the following clinical manifestations is commonly seen in individuals with immunodeficiency disorders?

Explanation: The correct answer is c. Severe combined immunodeficiency (SCID). SCID is a group of rare genetic disorders that affect both T cells and B cells, resulting in a severe impairment of the immune system. Individuals with SCID are highly susceptible to infections and may need to live in a protected environment to avoid exposure to pathogens, hence the term "bubble boy disease."

Incorrect choices:

a. DiGeorge syndrome is a primary immunodeficiency disorder characterized by abnormalities in the development of certain organs, including the thymus, leading to impaired T cell function, but it does not affect B cell function.

b. X-linked agammaglobulinemia is a primary immunodeficiency disorder characterized by a lack of mature B cells and an inability to produce antibodies, but it does not affect T cell function.

d. Acquired immunodeficiency syndrome (AIDS) is a secondary immunodeficiency disorder caused by the human immunodeficiency virus (HIV) infection, which specifically targets and destroys CD4+ T cells, but it does not affect B cell function.

Explanation: The correct answer is c. Frequent and severe infections. One of the hallmark features of immunodeficiency disorders is an increased susceptibility to infections. Individuals with immunodeficiencies may experience frequent and severe infections, including bacterial, viral, and fungal infections.

Incorrect choices:

a. Excessive inflammation at the site of infection is not a common clinical manifestation of immunodeficiency disorders. Immunodeficiencies are characterized by a weakened immune response, which may result in a reduced inflammatory response to infections.

b. Hyperactive immune response to allergens is seen in allergies and autoimmune disorders, not immunodeficiency disorders.

d. Immunodeficiency disorders are characterized by a lack or dysfunction of specific immune components, such as B cells or T cells, leading to a decreased production of antibodies, not increased.