Which of the following is a common clinical manifestation of immunodeficiency disorders?

Explanation: The correct answer is c. Allergic reactions and skin rashes are not typically associated with immunodeficiency disorders. Immunodeficiency disorders primarily result in an increased susceptibility to infections and recurrent, severe infections.

Incorrect choices:

a. Frequent, severe infections are a common symptom of immunodeficiency disorders due to the weakened immune response, making individuals more susceptible to infections.

b. Fatigue and weakness can occur in individuals with immunodeficiency disorders due to the impact of chronic infections on the body's energy reserves.

d. Delayed wound healing may occur in individuals with immunodeficiency disorders due to the impaired immune response and decreased ability to fight infections at the site of a wound.

Explanation: The correct answer is c. Severe combined immunodeficiency (SCID). SCID is a group of rare genetic disorders that affect both T cells and B cells, resulting in a severe impairment of the immune system. Individuals with SCID are highly susceptible to infections and may need to live in a protected environment to avoid exposure to pathogens, hence the term "bubble boy disease."

Incorrect choices:

a. DiGeorge syndrome is a primary immunodeficiency disorder characterized by abnormalities in the development of certain organs, including the thymus, leading to impaired T cell function, but it does not affect B cell function.

b. X-linked agammaglobulinemia is a primary immunodeficiency disorder characterized by a lack of mature B cells and an inability to produce antibodies, but it does not affect T cell function.

d. Acquired immunodeficiency syndrome (AIDS) is a secondary immunodeficiency disorder caused by the human immunodeficiency virus (HIV) infection, which specifically targets and destroys CD4+ T cells, but it does not affect B cell function.