Which of the following medications is used in the treatment of diabetes insipidus to control fluid balance?
Thiazide diuretics
Diabinese
Desmopressin (DDAVP)
Ibuprofen
The Correct Answer is C
Reasoning:
Choice A reason: Thiazide diuretics reduce urine output in nephrogenic diabetes insipidus by increasing sodium excretion, which enhances water reabsorption indirectly. However, they are not the primary treatment for central diabetes insipidus, where ADH deficiency is the issue. Desmopressin, an ADH analog, directly addresses the hormonal deficiency, making thiazides less effective.
Choice B reason: Diabinese (chlorpropamide) is a sulfonylurea used for type 2 diabetes mellitus, not diabetes insipidus. It lowers blood glucose by stimulating insulin release, which is irrelevant to the water balance issue in diabetes insipidus caused by ADH deficiency. It does not address the underlying hormonal imbalance.
Choice C reason: Desmopressin (DDAVP) is a synthetic ADH analog used to treat central diabetes insipidus. It mimics ADH, promoting water reabsorption in the kidneys’ collecting ducts, reducing polyuria and thirst. This directly corrects the fluid imbalance caused by ADH deficiency, making it the primary and most effective treatment.
Choice D reason: Ibuprofen, a nonsteroidal anti-inflammatory drug, is used for pain and inflammation, not for fluid balance in diabetes insipidus. It has no effect on ADH or renal water reabsorption, making it irrelevant for treating the excessive urine output and dehydration associated with this condition.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Reasoning:
Choice A reason: Antihypertensive treatment is not the priority for epidural hematoma, which causes rapid neurological deterioration from arterial bleeding and increased ICP. While hypertension may occur, surgical evacuation via burr holes is urgent to relieve pressure and prevent brain herniation, taking precedence over blood pressure management.
Choice B reason: Anticoagulant therapy is contraindicated in epidural hematoma, as it worsens bleeding. Epidural hematomas involve arterial hemorrhage, often from trauma, and anticoagulation would increase hematoma size, exacerbating ICP and neurological damage, making this an inappropriate and harmful intervention.
Choice C reason: Inserting an intracranial monitoring device may assess ICP but is not the priority in epidural hematoma. Rapid surgical intervention (burr holes) is needed to evacuate the hematoma and relieve life-threatening pressure, as monitoring delays critical treatment in this rapidly progressing condition.
Choice D reason: Burr holes are the priority intervention for epidural hematoma, a surgical emergency caused by arterial bleeding, often from skull trauma. Rapid evacuation of the hematoma relieves increased ICP, preventing brain herniation and death, making this the most urgent and effective treatment to stabilize the client.
Correct Answer is A
Explanation
Reasoning:
Choice A reason: Excessive thirst, or polydipsia, is a hallmark of diabetes insipidus. ADH deficiency leads to excessive water loss through dilute urine, causing dehydration. This triggers the thirst mechanism to compensate for fluid loss, prompting increased water intake to maintain hydration, a key clinical feature of this condition.
Choice B reason: Low urine output, or oliguria, is not associated with diabetes insipidus. This condition causes polyuria due to impaired water reabsorption from ADH deficiency, leading to large volumes of dilute urine. Low urine output is more typical of conditions like acute kidney injury or SIADH.
Choice C reason: Weight gain is not a feature of diabetes insipidus. The condition leads to water loss and dehydration, often causing weight loss due to reduced fluid volume. Weight gain might occur in conditions like SIADH, where water retention dilutes sodium and increases body fluid content.
Choice D reason: Excessive activities are not a clinical manifestation of diabetes insipidus. This condition primarily affects fluid balance, causing polyuria and polydipsia. Increased activity levels are not linked to ADH deficiency, and patients may experience fatigue due to dehydration, not heightened physical activity.
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