Which of the following medications is used in the treatment of diabetes insipidus to control fluid balance?
Thiazide diuretics
Diabinese
Desmopressin (DDAVP)
Ibuprofen
The Correct Answer is C
Reasoning:
Choice A reason: Thiazide diuretics reduce urine output in nephrogenic diabetes insipidus by increasing sodium excretion, which enhances water reabsorption indirectly. However, they are not the primary treatment for central diabetes insipidus, where ADH deficiency is the issue. Desmopressin, an ADH analog, directly addresses the hormonal deficiency, making thiazides less effective.
Choice B reason: Diabinese (chlorpropamide) is a sulfonylurea used for type 2 diabetes mellitus, not diabetes insipidus. It lowers blood glucose by stimulating insulin release, which is irrelevant to the water balance issue in diabetes insipidus caused by ADH deficiency. It does not address the underlying hormonal imbalance.
Choice C reason: Desmopressin (DDAVP) is a synthetic ADH analog used to treat central diabetes insipidus. It mimics ADH, promoting water reabsorption in the kidneys’ collecting ducts, reducing polyuria and thirst. This directly corrects the fluid imbalance caused by ADH deficiency, making it the primary and most effective treatment.
Choice D reason: Ibuprofen, a nonsteroidal anti-inflammatory drug, is used for pain and inflammation, not for fluid balance in diabetes insipidus. It has no effect on ADH or renal water reabsorption, making it irrelevant for treating the excessive urine output and dehydration associated with this condition.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Reasoning:
Choice A reason: Effective treatment of diabetes insipidus, typically with desmopressin, restores ADH function, reducing excessive urine output and thirst. Fluid intake below 2,500 ml/day indicates improved water reabsorption in the kidneys, normalizing fluid balance and reducing polyuria, which is a key sign of successful management of this condition.
Choice B reason: A heart rate of 126 beats/minute indicates tachycardia, often a sign of dehydration or hypovolemia in untreated diabetes insipidus. Effective treatment should normalize heart rate by correcting fluid balance, so persistent tachycardia suggests ongoing fluid loss and ineffective treatment, not a successful therapeutic outcome.
Choice C reason: Blood pressure of 90/50 mm Hg indicates hypotension, which can result from severe dehydration in untreated diabetes insipidus. Effective treatment should stabilize blood pressure by restoring fluid volume through improved water reabsorption, making low blood pressure an indicator of poor treatment response rather than success.
Choice D reason: Urine output exceeding 200 ml/hour reflects polyuria, a primary symptom of untreated diabetes insipidus due to ADH deficiency. Effective treatment reduces urine output by enhancing renal water reabsorption, so high urine output indicates persistent disease activity, not a successful response to therapy.
Correct Answer is C
Explanation
Reasoning:
Choice A reason: Feverfew, an herbal supplement, is sometimes used for migraines but has no proven role in aneurysm management. It may affect platelet function, increasing bleeding risk if an aneurysm ruptures, making it an inappropriate and potentially harmful recommendation for this client’s condition.
Choice B reason: Opioid analgesics are not routinely recommended for aneurysm management unless severe pain from rupture occurs. Prophylactic use is inappropriate, as it does not prevent aneurysm complications and may mask symptoms, delaying intervention. Lifestyle measures like avoiding strain are more relevant for prevention.
Choice C reason: Avoiding heavy lifting is critical for clients with an aneurysm, as increased intra-abdominal or thoracic pressure from lifting can elevate blood pressure, risking aneurysm rupture. This lifestyle modification reduces mechanical stress on the aneurysm wall, promoting safety and preventing catastrophic bleeding events.
Choice D reason: Including peanut butter, bread, or tart foods in the diet is unrelated to aneurysm management. Dietary choices do not directly affect aneurysm stability or rupture risk. Blood pressure control and avoiding strain, like heavy lifting, are more critical to prevent aneurysm complications.
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