Which of the following routes is affected by the first-pass effect?

Oral (PO)

Intravenous (IV)

Intramuscular (M)

Subcutaneous (SC)

Answer and Explanation

The Correct Answer is A

A.   The first-pass effect refers to the metabolism of a drug in the liver before it reaches systemic circulation. This primarily affects oral medications, as they are absorbed through the gastrointestinal tract and first pass through the liver.
B.   Intravenous (IV) drugs bypass the first-pass effect as they are directly introduced into the bloodstream.
C.   Intramuscular (IM) and D. Subcutaneous (SC) routes also bypass the first-pass effect since the drug enters the bloodstream without passing through the liver initially.

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Correct Answer is A

Explanation

A. Oral (PC): Naloxone undergoes rapid first-pass metabolism when taken orally, making it ineffective via this route.
B. Intravenous (IV): This is an effective route for naloxone administration.
C. Intramuscular (IM): This is also an effective route for naloxone administration.
D. Subcutaneous (SC): Naloxone can also be administered subcutaneously.

A. Pregnancy Risk Category A B. Pregnancy Risk Category B C. Pregnancy Risk Category C D. Pregnancy Risk Category D

Correct Answer is D

Explanation

A. This is incorrect. Raloxifene is not classified as Category A. It is not recommended during pregnancy.
B. Raloxifene is not classified as Category B. It poses risks to the fetus.
C. This is incorrect. Raloxifene is classified as Category X due to its potential harm to a developing fetus. D to potential harm to the fetus.

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Which of the following routes is affected by the first-pass effect?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer naloxone (Narcan). The nurse understands that this medication has a rapid first-pass inactivation. The nurse understands that naloxone (Narcan) be administered in all of the following routes EXCEPT for:

Correct Answer is A

Explanation

A nurse is providing an in-service on raloxifene (Evista) to a group of female clients. What is the pregnancy risk category of raloxifene (Evista)?

Correct Answer is D

Explanation

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