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Which one is not a step of pharmacokinetics?

A.

Distribution:

B.

Metabolism

C.

Absorption

D.

Synthesis

Answer and Explanation

The Correct Answer is D

A) Distribution:. Distribution refers to the process by which a drug is transported throughout the body after it is absorbed into the bloodstream. It involves the movement of the drug to various tissues and organs, where it can exert its effects. Factors such as blood flow, tissue permeability, and protein binding affect distribution.

 

B) Metabolism:
Metabolism refers to the biochemical process by which the body breaks down drugs into metabolites, usually in the liver. Metabolism can transform drugs into more easily excreted forms and sometimes alters the drug’s activity. It is essential for drug clearance and can affect drug efficacy and toxicity.

 

C) Absorption:
Absorption is the first step in pharmacokinetics, where the drug enters the bloodstream after being administered. It occurs primarily in the gastrointestinal (GI) tract for oral medications but can also happen in other routes like subcutaneous or intramuscular injections. The rate and extent of absorption are influenced by factors such as drug formulation, route of administration, and presence of food.

 

D) Synthesis:
Synthesis refers to the process of creating substances, such as drugs or other compounds, typically within the body or in a laboratory setting. While drug synthesis is crucial in drug development, it is not a step involved in the movement or processing of drugs within the body (which is what pharmacokinetics describes). Pharmacokinetics focuses on how the body handles drugs, not how they are created.


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Related Questions

Correct Answer is A

Explanation

1. Determine the total volume to be infused: 100 mL

2. Calculate the infusion time in minutes: 30 minutes

3. Calculate the drip rate (gtt/min):

Drip rate = (Total volume / Infusion time) x Drop factor

Drip rate = (100 mL / 30 minutes) x 15 gtt/mL

Drip rate = 50 gtt/min

Therefore, the correct answer is 50 gtt/min

Correct Answer is A

Explanation

Given:

Ordered dose of Heparin: 15 units/kg/hr

Patient weight: 82 kg

Total Heparin in solution: 25,000 units

Volume of solution: 250 mL

Step 1: Calculate the total dose of Heparin in units/hr:

Total dose (units/hr) = Ordered dose (units/kg/hr) x Patient weight (kg)

Total dose (units/hr) = 15 units/kg/hr x 82 kg

Total dose (units/hr) = 1230 units/hr

Step 2: Calculate the concentration of Heparin in the solution:

Concentration (units/mL) = Total Heparin (units) / Volume of solution (mL)

Concentration (units/mL) = 25,000 units / 250 mL

Concentration (units/mL) = 100 units/mL

Step 3: Calculate the infusion rate in mL/hr:

Infusion rate (mL/hr) = Total dose (units/hr) / Concentration (units/mL)

Infusion rate (mL/hr) = 1230 units/hr / 100 units/mL

Infusion rate (mL/hr) = 12.3 mL/hr

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