Which pathophysiologic events contribute to renal failure associated with tumor lysis syndrome?
Metabolic acidosis.
Elevated white blood cell count.
Crystallization of uric acid in the renal tubules.
Hypocalcemia.
The Correct Answer is C
Choice A rationale
Metabolic acidosis can occur in renal failure but is not directly linked to tumor lysis syndrome.
Choice B rationale
Elevated white blood cell count is not a primary contributor to renal failure in tumor lysis syndrome.
Choice C rationale
Crystallization of uric acid in the renal tubules can obstruct urine flow and cause acute renal failure, which is a direct pathophysiologic event in tumor lysis syndrome.
Choice D rationale
Hypocalcemia is a consequence of tumor lysis syndrome but does not directly cause renal failure.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A rationale
An RBC count of 5 million/mm³ is within the normal range for adult females, so this finding would not be concerning in the context of chemotherapy.
Choice B rationale
A WBC count of 2300/mm³ is significantly lower than the normal range (typically 4500 to 11000/mm³) and indicates neutropenia, which is a critical side effect of chemotherapy that needs to be reported immediately.
Choice C rationale
Hemoglobin level of 12 g/dL is within the normal range for adult females, so this would not be concerning in the context of chemotherapy.
Choice D rationale
A platelet count of 155,000/mm³ is within the normal range (150,000 to 450,000/mm³). Although on the lower end, it is not typically alarming enough to report immediately in the context of chemotherapy.
Correct Answer is C
Explanation
Choice A rationale
A mutant BRCA1 gene is not associated with an increased risk of thyroid cancer. Thyroid cancer risk factors include radiation exposure and family history, but not the BRCA1 mutation.
Choice B rationale
The BRCA1 gene mutation does not increase the risk of Down syndrome in offspring. Down syndrome is related to chromosomal abnormalities, not the BRCA1 gene mutation.
Choice C rationale
The BRCA1 gene mutation significantly increases the risk of breast cancer, often at an early age. It is a key factor in hereditary breast cancer syndromes.
Choice D rationale
The BRCA1 gene mutation is not linked to an increased risk of Alzheimer's disease. Alzheimer's is associated with genetic factors like the APOE gene, not BRCA1.
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