You are instructed to administer 40 mg of methadone (Dolophine) subcutaneously for opioid detoxification. Given that you have a concentration of 30 mg/mL on hand, how much should you draw into the syringe?

Choice A rationale:
Weight gain is the most objective and reliable indicator of improved nutritional status in patients with HIV-II and wasting syndrome. It directly reflects an increase in lean body mass, which is essential for restoring physical strength, immune function, and overall health.
A weight gain of 2 lb (1 kg) in a month is considered a clinically significant improvement for this patient population. It demonstrates that the patient is consuming more calories than they are expending, leading to a positive energy balance and tissue growth.
Other assessment findings, such as food intake, food choices, and oral discomfort, can be subjective and influenced by various factors, such as appetite, taste changes, nausea, fatigue, and psychosocial issues. While they provide valuable information about the patient's nutritional status, they do not directly measure the actual improvement in body composition.
Choice B rationale:
Consuming 90% of meals and snacks is a positive sign that the patient is adhering to their dietary recommendations. However, it does not guarantee that they are consuming enough calories to promote weight gain. The patient's individual energy needs and the nutritional content of the meals and snacks must be considered.
Choice C rationale:
Choosing high-protein foods is important for building and repairing tissues, but it does not ensure adequate overall caloric intake. The patient may still be experiencing a calorie deficit if they are not consuming enough total calories, even if they are focusing on protein-rich foods.
Choice D rationale:
Decreased oral discomfort can facilitate better food intake, but it does not directly reflect weight gain or improved nutritional status. The patient may still have challenges with appetite, nausea, or other factors that hinder their ability to consume enough calories.

Choice A rationale:
Uncompensated Respiratory Acidosis is characterized by a low pH (less than 7.35) and a high pCO2 (greater than 45 mmHg). In this case, the pH is slightly elevated (7.46), making this option less likely.
While the pCO2 is elevated (46 mmHg), the body has begun to compensate, as evidenced by the elevated HCO3 (29 mEq/L). This partial compensation does not align with an uncompensated respiratory acidosis.
Choice B rationale:
Compensated Metabolic Acidosis would present with a normal pH (7.35-7.45) due to full compensation by the respiratory system. In this case, the pH is slightly elevated (7.46), which is not consistent with full compensation.
Additionally, the HCO3 is elevated (29 mEq/L), which is characteristic of metabolic alkalosis, not acidosis.
Choice C rationale:
Partially Compensated Metabolic Alkalosis is the most likely interpretation based on the ABG results. The pH is elevated (7.46), indicating alkalosis.
The HCO3 is also elevated (29 mEq/L), which is the primary cause of metabolic alkalosis.
The pCO2 is elevated (46 mmHg), which is a compensatory mechanism to try to normalize the pH. However, the compensation is not complete, as the pH is still slightly elevated.
This partial compensation is consistent with partially compensated metabolic alkalosis.
Choice D rationale:
Partially Compensated Respiratory Acidosis would present with a low pH (less than 7.35) and an elevated pCO2 (greater than 45 mmHg).
The HCO3 would also be elevated, but to a lesser degree than in metabolic alkalosis, as it's a secondary compensatory mechanism.
In this case, the pH is slightly elevated (7.46), making respiratory acidosis less likely.