A client is inquiring about the genetic basis of cystic fibrosis (CF). Which statement by the nurse provides an accurate explanation?
"CF is caused by a dominant genetic mutation that always manifests in affected individuals."
"CF results from the presence of two recessive genetic mutations, one inherited from each parent."
"CF is due to a spontaneous genetic mutation that occurs during a person's lifetime."
"CF is exclusively caused by environmental factors and is not related to genetics."
The Correct Answer is B
A) Incorrect. CF is an autosomal recessive genetic disorder, meaning that both copies of the CFTR gene must carry a mutation for the condition to manifest.
B) Correct. CF is caused by the inheritance of two recessive genetic mutations, one from each parent, resulting in defective CFTR protein function.
C) Incorrect. CF is primarily a genetic disorder present from birth, not one caused by spontaneous mutations during a person's lifetime.
D) Incorrect. CF is primarily a genetic disorder with well-established genetic mutations associated with its development.
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Correct Answer is C
Explanation
A) Incorrect. Both partners having a family history of CF increases the likelihood of carrying CF gene mutations, making it possible for their child to inherit the condition.
B) Incorrect. Having a single CF gene mutation (carrier status) does not guarantee that a child will develop CF; it requires inheriting two CF gene mutations, one from each parent.
C) Correct. CF is an autosomal recessive genetic disorder, which means that a child will have CF only if they inherit two copies of the CF gene mutation, one from each parent.
D) Incorrect. The risk of a child having CF is determined by both parents' genetic history, not solely the mother's.
Correct Answer is B
Explanation
A) Incorrect. Genetic testing can confirm CF but is not typically the initial diagnostic test used in infants with symptoms suggestive of CF.
B) Correct. The sweat chloride test is often used as the initial diagnostic test to assess for CF in infants who exhibit symptoms.
C) Incorrect. Chest X-rays may be used to assess lung changes in individuals with CF but are not typically the initial diagnostic test in infants.
D) Incorrect. Pulmonary function tests are used to evaluate lung function but are not typically the initial diagnostic test for CF in infants.
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