The order reads "amoxicillin 20mg/kg/dose PO every 8 hours." The child weighs 33 pounds. Using the label below, how many mL will you administer per dose? (Enter a number only, answer to the nearest tenths place)

A) Use perfumes and air fresheners: Using perfumes and air fresheners may actually worsen nausea for some clients, as strong scents can trigger or exacerbate feelings of nausea, particularly in individuals undergoing chemotherapy. It is generally advisable to avoid strong odors in the environment to prevent triggering nausea.

B) Eat foods that are high in fibre: While a balanced diet is important, high-fibre foods may not be helpful in managing nausea and vomiting associated with chemotherapy. In fact, high-fibre foods can sometimes contribute to gastrointestinal discomfort, bloating, or constipation, which may worsen nausea in certain individuals. Therefore, fibre-rich foods are not the best option for reducing nausea and vomiting in this scenario.

C) Drink clear and carbonated beverages: Drinking clear liquids, such as water, ginger ale, or clear broths, can help reduce nausea by keeping the client hydrated and soothing the stomach. Carbonated beverages, such as ginger ale, are often recommended because the bubbles can help alleviate nausea and provide some relief. This is a well-established strategy for managing chemotherapy-related nausea and vomiting.

D) Walk frequently throughout the day: While physical activity is generally beneficial for overall health, walking frequently may not directly address nausea and vomiting caused by chemotherapy. In some cases, walking might even worsen nausea if the client is feeling weak or dizzy. Resting and staying hydrated may be more beneficial in the management of nausea associated with chemotherapy.

A) The drugs will compete for receptor sites: While it's true that highly protein-bound drugs can compete for binding sites on proteins (like albumin), the main issue with highly protein-bound drugs interacting is not related to competition for receptor sites. The primary concern is how the drugs displace each other from the protein-binding sites, which can increase the free (active) drug levels in the bloodstream. This can lead to a higher pharmacological effect, especially if the unbound drug concentration rises to a therapeutic or toxic level.

B) The client will have increased effects of both drugs: This is the correct answer. When two highly protein-bound drugs are administered together, they can displace each other from protein-binding sites. This displacement increases the amount of free (active) drug in circulation, which may intensify the pharmacologic effects of both drugs. For example, if one drug displaces the other from its protein-binding site, more of the free drug will be available to exert its effects. This can increase the risk of side effects, toxicity, or both.

C) The client will have decreased effects of both drugs: This is incorrect. The opposite is true—when two highly protein-bound drugs are given together, the displacement of one drug increases the amount of the free drug available, leading to a stronger effect, not a weaker one. Decreased effects would occur if the drug had no access to the target receptor or if it were metabolized or eliminated too quickly, which isn't the case in this scenario.

D) Both drugs are equally bound to protein: While both drugs may bind to protein, they do not necessarily bind equally. One drug might bind more strongly or more selectively to the protein than the other, which could lead to displacement of the weaker-bound drug. The important point is that their competition for protein-binding sites can lead to an increase in free (active) drug concentrations.