A doctor orders Vancomycin 500 mg to infuse at 5 mg/kg/hr. The patient weighs 98 lbs. You are supplied with a 500 mg/100 mL bag. How many mL/hr will you administer? (Round your answer to the nearest tenths)

A) Constipation:
ACE inhibitors primarily affect the cardiovascular system by inhibiting the enzyme responsible for converting angiotensin I to angiotensin II, a vasoconstrictor. Common side effects of ACE inhibitors include cough, dizziness, or elevated potassium levels, but constipation is not typically associated with these medications.

B) Headache:
While headaches can occasionally occur due to changes in blood pressure or other factors related to ACE inhibitors, it is not considered a hallmark side effect. More commonly, ACE inhibitors are associated with dizziness or lightheadedness, particularly when standing up quickly, due to their blood pressure-lowering effects.

C) Nonproductive cough:
A nonproductive cough is the most common and well-known side effect of ACE inhibitors. This occurs in some patients because of the accumulation of bradykinin, a substance that is normally broken down by the enzyme ACE. The buildup of bradykinin can lead to irritation in the airways, resulting in a dry, persistent cough. This side effect can be bothersome for patients and is one of the key reasons why ACE inhibitors might be switched to angiotensin II receptor blockers (ARBs) if the cough becomes intolerable.

D) Chest pain:
While ACE inhibitors work to lower blood pressure and improve heart function, they do not commonly cause chest pain. If a patient experiences chest pain while taking an ACE inhibitor, it is more likely related to other underlying conditions (e.g., heart disease or angina) rather than the medication itself.

Given:

Volume of fluid: 180 mL

Infusion time: 40 minutes

Step 1: Convert infusion time to hours:

Infusion time (hr) = 40 min / 60 min/hr

Infusion time (hr) = 0.67 hr

Step 2: Calculate the infusion rate in mL/hr:

Infusion rate (mL/hr) = Volume (mL) / Infusion time (hr)

Infusion rate (mL/hr) = 180 mL / 0.6667 hr

Infusion rate (mL/hr) = 269.987 mL/hr

Step 3: Round to the nearest whole number:

Infusion rate (mL/hr) ≈ 270 mL/hr