A nurse is caring for a client who has a prescription for hydrochlorothiazide for the initial treatment of hypertension.
Which of the following should the nurse recognize as the action of this medication?
Hydrochlorothiazide prevents angiotensin II from binding with receptor sites.
Hydrochlorothiazide decreases the reabsorption of sodium and water in the distal renal tubule.
Hydrochlorothiazide blocks stimulation of beta receptors in the sympathetic nervous system.
Hydrochlorothiazide promotes the movement of extravascular fluids into the vascular compartment.
The Correct Answer is B
Choice A rationale
Hydrochlorothiazide does not interact with angiotensin II receptors. Instead, it affects electrolyte balance in the kidney by inhibiting sodium and chloride reabsorption, leading to increased urine output and reduction in blood pressure.
Choice B rationale
Hydrochlorothiazide decreases sodium and water reabsorption in the distal tubules, increasing urine production. This diuretic action reduces blood volume and subsequently decreases blood pressure, effectively treating hypertension.
Choice C rationale
Hydrochlorothiazide does not block beta receptors. Beta blockers reduce heart rate and decrease cardiac output to lower blood pressure. Hydrochlorothiazide acts as a diuretic, not a beta receptor antagonist.
Choice D rationale
Hydrochlorothiazide does not promote movement of extravascular fluids into the vascular compartment. It decreases blood volume by reducing fluid retention through increased urine output, thereby lowering blood pressure.
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Related Questions
Correct Answer is C
Explanation
Choice A rationale
Alanine aminotransferase (ALT) monitors liver function. While captopril is metabolized by the liver, it is not the most critical value to monitor. Elevated ALT may indicate liver damage, but it is not a primary concern with captopril.
Choice B rationale
Thyroid-stimulating hormone (TSH) is related to thyroid function. Captopril does not typically affect thyroid function, so monitoring TSH levels is not a priority. The focus is on electrolytes and kidney function with captopril.
Choice C rationale
Potassium monitoring is essential due to the risk of hyperkalemia with captopril. Captopril, an ACE inhibitor, can increase potassium levels by reducing aldosterone secretion. Normal potassium range is 3.5 to 5 mEq/L.
Choice D rationale
Magnesium levels are important for various bodily functions, but captopril does not significantly affect magnesium. Monitoring potassium and renal function is more critical due to the potential for hyperkalemia with captopril. .
Correct Answer is A
Explanation
Choice A rationale
Removing the patch for two to four hours daily helps prevent tolerance development by allowing nitrate-free intervals, thus maintaining the effectiveness of nitroglycerin.
Choice B rationale
Applying a new patch each day after waking up ensures continuous delivery of nitroglycerin; however, this does not provide nitrate-free intervals necessary to avoid tolerance.
Choice C rationale
Covering the patch with plastic wrap can increase the risk of overdose by enhancing nitroglycerin absorption, which may lead to severe hypotension and other adverse effects.
Choice D rationale
Replacing the patch as soon as anginal pain begins does not allow for a consistent delivery system and may lead to erratic blood levels of nitroglycerin, reducing its effectiveness.
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