A nurse is caring for a client who has a sulfonamide allergy. Which of the following medications should the nurse identify as contraindicated?

A. Digoxin and levothyroxine. These medications do not typically interact to cause hearing loss. Digoxin is used for heart conditions, and levothyroxine is a thyroid hormone replacement. Their interaction does not pose a risk for ototoxicity.
B. Furosemide and amikacin. This combination is known to cause ototoxicity. Furosemide is a loop diuretic, and amikacin is an aminoglycoside antibiotic. Both drugs have ototoxic potential, and their combined use increases the risk of hearing loss.
C. Losartan and atorvastatin. These medications do not typically interact to cause hearing loss. Losartan is an antihypertensive, and atorvastatin is a cholesterol-lowering agent. Their interaction does not pose a risk for ototoxicity.
D. Propranolol and raloxifene. These medications do not typically interact to cause hearing loss. Propranolol is a beta-blocker, and raloxifene is used for osteoporosis. Their interaction does not pose a risk for ototoxicity.

A. Oxycodone promotes vasodilation of cranial arteries. This is not the primary mechanism by which oxycodone affects respiratory rate. Vasodilation of cranial arteries is not directly related to respiratory depression.
B. Oxycodone blocks the sodium channel suspending nerve conduction. This is not the primary mechanism of action for oxycodone. Oxycodone primarily acts on opioid receptors rather than sodium channels.
C. Oxycodone inhibits prostaglandin synthesis. This is not the primary mechanism of action for oxycodone. Inhibition of prostaglandin synthesis is more characteristic of nonsteroidal anti-inflammatory drugs (NSAIDs).
D. Oxycodone causes central nervous system depression. This is the correct explanation. Oxycodone, like other opioids, depresses the central nervous system, which can lead to respiratory depression by reducing the brainstem’s responsiveness to carbon dioxide levels in the blood.