A nurse is caring for a client who has malaria and is prescribed chloroquine. What is the mechanism of action of this drug?

It inhibits heme polymerization in the parasite.

It disrupts mitochondrial function in the parasite.

It interferes with DNA synthesis in the parasite.

It blocks calcium influx in the parasite.

Answer and Explanation

The Correct Answer is A

Chloroquine inhibits heme polymerization in the parasite, which causes the accumulation of toxic heme and kills the parasite.

Choice B is wrong because chloroquine does not disrupt mitochondrial function in the parasite.

Choice C is wrong because chloroquine does not interfere with DNA synthesis in the parasite.

Choice D is wrong because chloroquine does not block calcium influx in the parasite.

Heme polymerization is the process of converting heme, a toxic byproduct of hemoglobin digestion, into hemozoin, a nontoxic pigment that can be stored by the parasite. Chloroquine forms a complex with heme and prevents it from polymerizing, thus disrupting the parasite’s metabolism and survival.

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Correct Answer is D

Explanation

Rifampin is a drug that can interact with atovaquone-proguanil and reduce its effectiveness in preventing or treating malaria.Rifampin can lower the blood levels of atovaquone and proguanil by increasing their metabolism in the liver. Therefore, rifampin should be avoided or used with caution when taking atovaquone-proguanil.

Choice A is wrong because warfarin is not a known interaction with atovaquone-proguanil.

Warfarin is a blood thinner that can interact with many other drugs, but atovaquone-proguanil is not one of them.

Choice B is wrong because metformin is not a known interaction with atovaquone-proguanil.

Metformin is a drug that lowers blood sugar levels in people with diabetes.

It does not affect the metabolism or efficacy of atovaquone-proguanil.

Choice C is wrong because omeprazole is not a known interaction with atovaquone-proguanil.

Omeprazole is a drug that reduces stomach acid production and treats ulcers and reflux.

It does not interfere with the absorption or action of atovaquone-proguanil.

A. “I should apply the cream twice a day for 2 weeks.” B. “I should wash my feet with soap and water before applying the cream.” C. “I should cover the affected area with a bandage after applying the cream.” D. “I should stop using the cream if I develop itching or burning."

Correct Answer is A

Explanation

This statement indicates that the client understands the proper use of terbinafine cream for tinea pedis, which is a fungal infection of the feet.Terbinafine cream is an antifungal agent that works by killing the fungus or preventing its growth.According to a study, terbinafine 1% cream applied once daily for 7 days is effective in treating interdigital tinea pedis, but some sources recommend applying it twice daily for 2 weeks.

Choice B is wrong because washing the feet with soap and water before applying the cream is not necessary and may cause irritation or dryness of the skin.

Choice C is wrong because covering the affected area with a bandage after applying the cream is not advised and may create a moist environment that favors fungal growth.

Choice D is wrong because itching or burning are common side effects of terbinafine cream and do not indicate an allergic reaction or a need to stop using the cream.However, if the symptoms are severe or persist, the client should contact their health care provider.

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A nurse is caring for a client who has malaria and is prescribed chloroquine. What is the mechanism of action of this drug?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is reviewing the medication history of a client who is prescribed atovaquone-proguanil for malaria prophylaxis. Which of the following medications should the nurse identify as a potential interaction with atovaquone-proguanil?

Correct Answer is D

Explanation

A nurse is educating a client who has tinea pedis about the use of terbinafine cream. Which of the following statements by the client indicates an understanding of the teaching?

Correct Answer is A

Explanation

A nurse is reviewing the medication history of a client who has a fungal infection and is prescribed caspofungin. The nurse should identify that which of the following medications can interact with caspofungin?

A nurse is caring for a client who has a viral infection. The client asks the nurse how nucleoside analogs work to treat viral infections. Which of the following statements by the nurse is correct?

A nurse is caring for a client who has a viral infection and is taking an antiviral medication that inhibits the integrase enzyme that is essential for viral DNA integration into host cell genome. Which of the following antiviral groups does this medication belong to?

A nurse is caring for a client who has a fungal infection and is prescribed amphotericin. What adverse effects should the nurse monitor for in this client?

A nurse is teaching a client who has a vaginal candidiasis infection about the use of miconazole cream. Which of the following instructions should the nurse include? (Select all that apply.).

A nurse is caring for a client who has a viral infection. Which of the following antiviral groups bind to and inhibit viral reverse transcriptase enzyme that is essential for viral RNA synthesis? (Select all that apply)

A nurse is administering albendazole to a client who has a tapeworm infection. The client asks how the drug works. Which of the following responses should the nurse give?

A nurse is caring for a client who has a viral infection. Which of the following antiviral groups inhibits viral DNA polymerase or reverse transcriptase enzymes that are essential for viral DNA or RNA synthesis?