A nurse is preparing to administer 0.45% NaCl 250 mL IV to infuse over 90 minutes. The drop factor of the manual IV tubing is 15 gtt/mL. What is the flow rate in gtt/min? (Round to the nearest whole number & fill in the blank with the numerical value only)

A. "I will need to take this medication for several weeks before noticing its full effects.": Buspirone is an anxiolytic that works by modulating serotonin and dopamine receptors. Unlike benzodiazepines, it has a delayed onset of action, typically requiring 2–4 weeks of consistent use to achieve its full therapeutic benefit.
B. "If I don't feel better after one week, I will stop taking the medication.": Stopping Buspirone prematurely can prevent the medication from reaching its full effect. It requires patient adherence and time for therapeutic levels to build; discontinuation should only be under a provider’s guidance.
C. "I should feel less anxious within an hour of taking the first dose.": Buspirone does not provide immediate relief of anxiety symptoms. It is not effective for acute anxiety or panic attacks due to its slow onset and gradual buildup in the system.
D. "I can use this medication as needed when I feel a panic attack coming on.": Buspirone is not intended for PRN (as-needed) use. It must be taken on a scheduled basis to maintain steady blood levels and is not useful for rapid symptom relief in panic situations.

A. It increases the metabolism of drugs in the liver: Grapefruit juice actually inhibits, rather than increases, the activity of liver enzymes particularly CYP3A4 resulting in slower drug metabolism and higher plasma concentrations of certain medications.
B. It decreases the absorption of medications: Grapefruit juice does not generally reduce drug absorption. In fact, by inhibiting intestinal enzymes, it can increase the absorption and bioavailability of some drugs, potentially raising them to toxic levels.
C. It only affects medications taken in the morning: The interaction is not time-specific. Grapefruit juice can affect drug metabolism even when consumed hours apart from the medication, as enzyme inhibition can persist for up to 24–72 hours.
D. It blocks the action of enzymes, leading to increased drug levels in the blood: Grapefruit juice inhibits cytochrome P450 enzymes especially CYP3A4 in the intestinal wall. This results in decreased drug breakdown and higher systemic concentrations, increasing the risk of adverse effects and toxicity.