A nurse is preparing to administer a lipophilic medication to a client with a high body fat percentage. What should the nurse consider?

The client may require a higher dose of the medication.

The client may require a lower dose of the medication.

The client may require more frequent dosing of the medication.

The client’s body fat percentage does not affect pharmacokinetics.

Answer and Explanation

The Correct Answer is A

Lipophilic medications are soluble in fat and can accumulate in adipose tissue, reducing their concentration in plasma and potentially reducing their therapeutic effect. A client with a high body fat percentage may require a higher dose of a lipophilic medication to achieve therapeutic levels.

b. The client may require a higher, not lower, dose of the medication due to accumulation in adipose tissue.

c. More frequent dosing may not be necessary if an appropriate dose is administered.

d. The client’s body fat percentage can affect pharmacokinetics by altering distribution of lipophilic medications.

Nursing Test Bank

Quiz #1: RN Exams Pharmacology Exams Quiz #2: RN Exams Medical-Surgical Exams Quiz #3: RN Exams Fundamentals Exams Quiz #4: RN Exams Maternal-Newborn Exams Quiz #5: RN Exams Anatomy and Physiology Exams Quiz #6: RN Exams Obstetrics and Pediatrics Exams Quiz #7: RN Exams Fluid and Electrolytes Exams Quiz #8: RN Exams Community Health Exams Quiz #9: RN Exams Promoting Health across the lifespan Exams Quiz #10: RN Exams Multidimensional care Exams

Get 100+ Naxlex Exit Exams for $79 Try Naxlex NCLEX-RN (14 Day Free-Trial)

Naxlex Comprehensive Predictor Exams

Quiz #1: Naxlex RN Comprehensive online practice 2019 B with NGN Quiz #2: Naxlex RN Comprehensive Predictor 2023 Quiz #3: Naxlex RN Comprehensive Predictor 2023 Exit Exam A Quiz #4: Naxlex HESI Exit LPN Exam Quiz #5: Naxlex PN Comprehensive Predictor PN 2020 Quiz #6: Naxlex VATI PN Comprehensive Predictor 2020 Quiz #8: Naxlex PN Comprehensive Predictor 2023 - Exam 1 Quiz #10: Naxlex HESI PN Exit exam Quiz #11: Naxlex HESI PN EXIT Exam 2

Free Nursing Study Resources

Correct Answer is B

Explanation

Medications that are primarily excreted by the kidneys can accumulate in clients with renal impairment, potentially leading to toxicity.A client with renal impairment may require a lower dose of a medication that is primarily excreted by the kidneys to avoid accumulation and toxicity.

a.The client may require a lower, not higher, dose of the medication due to reduced renal excretion.

c.More frequent dosing may not be necessary if an appropriate dose is administered.

d.The client’s renal function can affect pharmacokinetics by altering excretion of medications that are primarily eliminated by the kidneys.

A. There is an increased risk of drug interactions B. There is a decreased risk of drug interactions C. There is no risk of drug interactions D. P-glycoprotein inhibition does not affect pharmacokinetics

Correct Answer is A

Explanation

P-glycoprotein is a membrane protein that pumps certain drugs out of cells and can affect their absorption, distribution, and elimination. Inhibition of P-glycoprotein can increase the concentration of other medications that are substrates for this protein, potentially increasing their therapeutic effect and the risk of drug interactions.

b. There is an increased, not decreased, risk of drug interactions due to increased concentration of other medications that are substrates for P-glycoprotein.

c. There is an increased risk of drug interactions due to increased concentration of other medications that are substrates for P-glycoprotein.

d. P-glycoprotein inhibition can affect pharmacokinetics by altering absorption, distribution, and elimination of other medications that are substrates for this protein.

View Question and Answer

Whether you are a student looking to ace your exams or a practicing nurse seeking to enhance your expertise , our nursing education contents will empower you with the confidence and competence to make a difference in the lives of patients and become a respected leader in the healthcare field.

Visit Naxlex, invest in your future and unlock endless possibilities with our unparalleled nursing education contents today

A nurse is preparing to administer a lipophilic medication to a client with a high body fat percentage. What should the nurse consider?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer a medication that is primarily excreted by the kidneys.What should be considered when administering this drug to a client with renal impairment?

Correct Answer is B

Explanation

A nurse is preparing to administer a medication that inhibits P-glycoprotein.What should be considered when administering this drug with other medications?

Correct Answer is A

Explanation

A nurse is preparing to administer a medication that is highly protein bound.What should be considered when administering this drug to a client with hypoalbuminemia?

A nurse is preparing to administer a weakly acidic medication to a client with an elevated gastric pH due to antacid use. What should the nurse consider?

A nurse is preparing to administer a medication that induces CYP450 enzymes.What should be considered when administering this drug with other medications?

A nurse is preparing to administer a medication that undergoes enterohepatic recirculation.What should be considered when administering this drug?

A nurse is preparing to administer a medication that has a narrow therapeutic index. What action should the nurse take?

A nurse is preparing to administer a lipophilic medication to a client with a high body fat percentage. What should the nurse consider?

A nurse is preparing to administer a prodrug that requires activation by hepatic enzymes.What should be considered when administering this drug?

A nurse is preparing to administer a medication that undergoes extensive first-pass metabolism. What route of administration should be used?