A nurse is preparing to administer a medication that has a narrow therapeutic index. What action should the nurse take?

Administer the medication as prescribed.

Hold the medication and notify the provider.

Administer half the dose of the medication.

Administer the medication with food or milk.

Answer and Explanation

The Correct Answer is B

A medication with a narrow therapeutic index has a small margin of safety between its therapeutic and toxic doses. The nurse should hold the medication and notify the provider to ensure that the client’s drug levels are within the therapeutic range and to avoid potential toxicity.

a. Administering the medication as prescribed could result in toxicity if the client’s drug levels are not within the therapeutic range.

c. Administering half the dose of the medication is not appropriate without consulting the provider and monitoring the client’s drug levels.

d. Administering the medication with food or milk may affect its absorption but does not prevent potential toxicity.

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Correct Answer is A

Explanation

Lipophilic medications are soluble in fat and can accumulate in adipose tissue, reducing their concentration in plasma and potentially reducing their therapeutic effect. A client with a high body fat percentage may require a higher dose of a lipophilic medication to achieve therapeutic levels.

b. The client may require a higher, not lower, dose of the medication due to accumulation in adipose tissue.

c. More frequent dosing may not be necessary if an appropriate dose is administered.

d. The client’s body fat percentage can affect pharmacokinetics by altering distribution of lipophilic medications.

A. The drug will have a shorter half-life B. The drug will have a longer half-life C. The drug will have increased bioavailability D. The drug will have decreased bioavailability

Correct Answer is B

Explanation

Enterohepatic recirculation refers to the process by which a drug or its metabolites are excreted into bile, reabsorbed from the intestines, and returned to the liver.Medications that undergo enterohepatic recirculation can have a longer half-life due to repeated reabsorption and recirculation.

a.The drug will have a longer, not shorter, half-life due to repeated reabsorption and recirculation.

c.Enterohepatic recirculation can affect half-life but does not directly affect bioavailability.

d.Enterohepatic recirculation can affect half-life but does not directly affect bioavailability.

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A nurse is preparing to administer a medication that has a narrow therapeutic index. What action should the nurse take?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer a lipophilic medication to a client with a high body fat percentage. What should the nurse consider?

Correct Answer is A

Explanation

A nurse is preparing to administer a medication that undergoes enterohepatic recirculation.What should be considered when administering this drug?

Correct Answer is B

Explanation

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