A nurse is preparing to administer a medication that has a narrow therapeutic index. What action should the nurse take?

Administer the medication as prescribed.

Hold the medication and notify the provider.

Administer half the dose of the medication.

Administer the medication with food or milk.

Answer and Explanation

The Correct Answer is B

A medication with a narrow therapeutic index has a small margin of safety between its therapeutic and toxic doses. The nurse should hold the medication and notify the provider to ensure that the client’s drug levels are within the therapeutic range and to avoid potential toxicity.

a. Administering the medication as prescribed could result in toxicity if the client’s drug levels are not within the therapeutic range.

c. Administering half the dose of the medication is not appropriate without consulting the provider and monitoring the client’s drug levels.

d. Administering the medication with food or milk may affect its absorption but does not prevent potential toxicity.

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Correct Answer is A

Explanation

A prodrug is an inactive compound that requires conversion into its active form by metabolic processes such as hepatic enzyme activation.Giving a prodrug with an enzyme inducer can increase the activity of the hepatic enzymes responsible for converting the prodrug into its active form, potentially increasing its efficacy.

a.Giving the drug with food may affect its absorption but does not directly affect its activation by hepatic enzymes.

b.Giving the drug with food may affect its absorption but does not directly affect its activation by hepatic enzymes.

c.Giving the drug with an enzyme inducer, not an enzyme inhibitor, can increase its efficacy by increasing hepatic enzyme activity.

A. There is an increased risk of drug interactions B. There is a decreased risk of drug interactions C. There is no risk of drug interactions D. P-glycoprotein inhibition does not affect pharmacokinetics

Correct Answer is A

Explanation

P-glycoprotein is a membrane protein that pumps certain drugs out of cells and can affect their absorption, distribution, and elimination. Inhibition of P-glycoprotein can increase the concentration of other medications that are substrates for this protein, potentially increasing their therapeutic effect and the risk of drug interactions.

b. There is an increased, not decreased, risk of drug interactions due to increased concentration of other medications that are substrates for P-glycoprotein.

c. There is an increased risk of drug interactions due to increased concentration of other medications that are substrates for P-glycoprotein.

d. P-glycoprotein inhibition can affect pharmacokinetics by altering absorption, distribution, and elimination of other medications that are substrates for this protein.

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A nurse is preparing to administer a medication that has a narrow therapeutic index. What action should the nurse take?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer a prodrug that requires activation by hepatic enzymes.What should be considered when administering this drug?

Correct Answer is A

Explanation

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Correct Answer is A

Explanation

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