A nurse is preparing to administer a medication that is primarily excreted by the kidneys.What should be considered when administering this drug to a client with renal impairment?

The client may require a higher dose of the medication

The client may require a lower dose of the medication

The client may require more frequent dosing of the medication

The client’s renal function does not affect pharmacokinetics

Answer and Explanation

The Correct Answer is B

Medications that are primarily excreted by the kidneys can accumulate in clients with renal impairment, potentially leading to toxicity.A client with renal impairment may require a lower dose of a medication that is primarily excreted by the kidneys to avoid accumulation and toxicity.

a.The client may require a lower, not higher, dose of the medication due to reduced renal excretion.

c.More frequent dosing may not be necessary if an appropriate dose is administered.

d.The client’s renal function can affect pharmacokinetics by altering excretion of medications that are primarily eliminated by the kidneys.

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Correct Answer is B

Explanation

Weakly acidic medications are more readily absorbed in an acidic environment because they are more likely to be in their non-ionized, lipid-soluble form which can easily cross cell membranes and enter systemic circulation. An elevated gastric pH due to antacid use can reduce absorption of weakly acidic medications by increasing ionization and reducing lipid solubility.

a. The medication will have decreased, not increased, absorption in an alkaline environment due to increased ionization.

c. The antacid can affect absorption by altering gastric pH and increasing ionization of weakly acidic medications.

d. The antacid can affect absorption but does not directly affect excretion of weakly acidic medications.

A. The drug will have a shorter half-life B. The drug will have a longer half-life C. The drug will have increased bioavailability D. The drug will have decreased bioavailability

Correct Answer is B

Explanation

Enterohepatic recirculation refers to the process by which a drug or its metabolites are excreted into bile, reabsorbed from the intestines, and returned to the liver.Medications that undergo enterohepatic recirculation can have a longer half-life due to repeated reabsorption and recirculation.

a.The drug will have a longer, not shorter, half-life due to repeated reabsorption and recirculation.

c.Enterohepatic recirculation can affect half-life but does not directly affect bioavailability.

d.Enterohepatic recirculation can affect half-life but does not directly affect bioavailability.

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A nurse is preparing to administer a medication that is primarily excreted by the kidneys.What should be considered when administering this drug to a client with renal impairment?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer a weakly acidic medication to a client with an elevated gastric pH due to antacid use. What should the nurse consider?

Correct Answer is B

Explanation

A nurse is preparing to administer a medication that undergoes enterohepatic recirculation.What should be considered when administering this drug?

Correct Answer is B

Explanation

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