A nurse is preparing to administer a medication that is primarily excreted by the kidneys.What should be considered when administering this drug to a client with renal impairment?
The client may require a higher dose of the medication
The client may require a lower dose of the medication
The client may require more frequent dosing of the medication
The client’s renal function does not affect pharmacokinetics
The Correct Answer is B
Medications that are primarily excreted by the kidneys can accumulate in clients with renal impairment, potentially leading to toxicity.A client with renal impairment may require a lower dose of a medication that is primarily excreted by the kidneys to avoid accumulation and toxicity.
a.The client may require a lower, not higher, dose of the medication due to reduced renal excretion.
c.More frequent dosing may not be necessary if an appropriate dose is administered.
d.The client’s renal function can affect pharmacokinetics by altering excretion of medications that are primarily eliminated by the kidneys.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Medications that are highly protein bound bind to plasma proteins such as albumin, reducing their free fraction and potentially reducing their therapeutic effect.A client with hypoalbuminemia may have an increased free fraction of a highly protein-bound medication due to reduced protein binding, potentially increasing its therapeutic effect.
b.The client may have an increased, not decreased, free fraction of the drug due to reduced protein binding.
c.An increased volume of distribution may occur if protein binding is reduced, but this is not directly related to hypoalbuminemia.
d.The client’s albumin levels can affect pharmacokinetics by altering protein binding of highly protein-bound medications.
Correct Answer is B
Explanation
Medications that are primarily excreted by the kidneys can accumulate in clients with renal impairment, potentially leading to toxicity.A client with renal impairment may require a lower dose of a medication that is primarily excreted by the kidneys to avoid accumulation and toxicity.
a.The client may require a lower, not higher, dose of the medication due to reduced renal excretion.
c.More frequent dosing may not be necessary if an appropriate dose is administered.
d.The client’s renal function can affect pharmacokinetics by altering excretion of medications that are primarily eliminated by the kidneys.
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