A nurse is preparing to administer a medication that undergoes enterohepatic recirculation.What should be considered when administering this drug?

The drug will have a shorter half-life

The drug will have a longer half-life

The drug will have increased bioavailability

The drug will have decreased bioavailability

Answer and Explanation

The Correct Answer is B

Enterohepatic recirculation refers to the process by which a drug or its metabolites are excreted into bile, reabsorbed from the intestines, and returned to the liver.Medications that undergo enterohepatic recirculation can have a longer half-life due to repeated reabsorption and recirculation.

a.The drug will have a longer, not shorter, half-life due to repeated reabsorption and recirculation.

c.Enterohepatic recirculation can affect half-life but does not directly affect bioavailability.

d.Enterohepatic recirculation can affect half-life but does not directly affect bioavailability.

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Correct Answer is A

Explanation

P-glycoprotein is a membrane protein that pumps certain drugs out of cells and can affect their absorption, distribution, and elimination. Inhibition of P-glycoprotein can increase the concentration of other medications that are substrates for this protein, potentially increasing their therapeutic effect and the risk of drug interactions.

b. There is an increased, not decreased, risk of drug interactions due to increased concentration of other medications that are substrates for P-glycoprotein.

c. There is an increased risk of drug interactions due to increased concentration of other medications that are substrates for P-glycoprotein.

d. P-glycoprotein inhibition can affect pharmacokinetics by altering absorption, distribution, and elimination of other medications that are substrates for this protein.

A. The drug will have increased efficacy if given with food B. The drug will have decreased efficacy if given with food C. The drug will have decreased efficacy if given with an enzyme inducer D. The drug will have increased efficacy if given with an enzyme inducer

Correct Answer is A

Explanation

A prodrug is an inactive compound that requires conversion into its active form by metabolic processes such as hepatic enzyme activation.Giving a prodrug with an enzyme inducer can increase the activity of the hepatic enzymes responsible for converting the prodrug into its active form, potentially increasing its efficacy.

a.Giving the drug with food may affect its absorption but does not directly affect its activation by hepatic enzymes.

b.Giving the drug with food may affect its absorption but does not directly affect its activation by hepatic enzymes.

c.Giving the drug with an enzyme inducer, not an enzyme inhibitor, can increase its efficacy by increasing hepatic enzyme activity.

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A nurse is preparing to administer a medication that undergoes enterohepatic recirculation.What should be considered when administering this drug?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer a medication that inhibits P-glycoprotein.What should be considered when administering this drug with other medications?

Correct Answer is A

Explanation

A nurse is preparing to administer a prodrug that requires activation by hepatic enzymes.What should be considered when administering this drug?

Correct Answer is A

Explanation

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