A nurse is preparing to administer a medication that undergoes enterohepatic recirculation.What should be considered when administering this drug?

The drug will have a shorter half-life

The drug will have a longer half-life

The drug will have increased bioavailability

The drug will have decreased bioavailability

Answer and Explanation

The Correct Answer is B

Enterohepatic recirculation refers to the process by which a drug or its metabolites are excreted into bile, reabsorbed from the intestines, and returned to the liver.Medications that undergo enterohepatic recirculation can have a longer half-life due to repeated reabsorption and recirculation.

a.The drug will have a longer, not shorter, half-life due to repeated reabsorption and recirculation.

c.Enterohepatic recirculation can affect half-life but does not directly affect bioavailability.

d.Enterohepatic recirculation can affect half-life but does not directly affect bioavailability.

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Correct Answer is B

Explanation

Weakly acidic medications are more readily absorbed in an acidic environment because they are more likely to be in their non-ionized, lipid-soluble form which can easily cross cell membranes and enter systemic circulation. An elevated gastric pH due to antacid use can reduce absorption of weakly acidic medications by increasing ionization and reducing lipid solubility.

a. The medication will have decreased, not increased, absorption in an alkaline environment due to increased ionization.

c. The antacid can affect absorption by altering gastric pH and increasing ionization of weakly acidic medications.

d. The antacid can affect absorption but does not directly affect excretion of weakly acidic medications.

A. The client may require a higher dose of the medication. B. The client may require a lower dose of the medication. C. The client may require more frequent dosing of the medication. D. The client’s body fat percentage does not affect pharmacokinetics.

Correct Answer is A

Explanation

Lipophilic medications are soluble in fat and can accumulate in adipose tissue, reducing their concentration in plasma and potentially reducing their therapeutic effect. A client with a high body fat percentage may require a higher dose of a lipophilic medication to achieve therapeutic levels.

b. The client may require a higher, not lower, dose of the medication due to accumulation in adipose tissue.

c. More frequent dosing may not be necessary if an appropriate dose is administered.

d. The client’s body fat percentage can affect pharmacokinetics by altering distribution of lipophilic medications.

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A nurse is preparing to administer a medication that undergoes enterohepatic recirculation.What should be considered when administering this drug?

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Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer a weakly acidic medication to a client with an elevated gastric pH due to antacid use. What should the nurse consider?

Correct Answer is B

Explanation

A nurse is preparing to administer a lipophilic medication to a client with a high body fat percentage. What should the nurse consider?

Correct Answer is A

Explanation

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