A nurse is preparing to administer a medication that undergoes extensive first-pass metabolism. What route of administration should be used?
Oral
Intravenous
Subcutaneous
Intramuscular
The Correct Answer is B
First-pass metabolism refers to the metabolism of a drug by the liver before it reaches systemic circulation. Drugs that undergo extensive first-pass metabolism have a lower bioavailability when administered orally because a significant portion of the drug is metabolized before it reaches systemic circulation. Intravenous administration bypasses first-pass metabolism and delivers the drug directly into systemic circulation.
a. Oral administration would result in lower bioavailability due to first-pass metabolism.
c. Subcutaneous administration may also be subject to first-pass metabolism.
d. Intramuscular administration may also be subject to first-pass metabolism.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Weakly acidic medications are more readily absorbed in an acidic environment because they are more likely to be in their non-ionized, lipid-soluble form which can easily cross cell membranes and enter systemic circulation. An elevated gastric pH due to antacid use can reduce absorption of weakly acidic medications by increasing ionization and reducing lipid solubility.
a. The medication will have decreased, not increased, absorption in an alkaline environment due to increased ionization.
c. The antacid can affect absorption by altering gastric pH and increasing ionization of weakly acidic medications.
d. The antacid can affect absorption but does not directly affect excretion of weakly acidic medications.
Correct Answer is B
Explanation
First-pass metabolism refers to the metabolism of a drug by the liver before it reaches systemic circulation. Drugs that undergo extensive first-pass metabolism have a lower bioavailability when administered orally because a significant portion of the drug is metabolized before it reaches systemic circulation. Intravenous administration bypasses first-pass metabolism and delivers the drug directly into systemic circulation.
a. Oral administration would result in lower bioavailability due to first-pass metabolism.
c. Subcutaneous administration may also be subject to first-pass metabolism.
d. Intramuscular administration may also be subject to first-pass metabolism.
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