A nurse is preparing to administer a medication that induces CYP450 enzymes.What should be considered when administering this drug with other medications?

There is an increased risk of drug interactions

There is a decreased risk of drug interactions

There is no risk of drug interactions

CYP450 induction does not affect pharmacokinetics

Answer and Explanation

The Correct Answer is A

CYP450 enzymes are responsible for metabolizing many medications.Induction of CYP450 enzymes can increase their activity and accelerate metabolism of other medications that are substrates for these enzymes, potentially reducing their therapeutic effect and increasing the risk of drug interactions.

b.There is an increased, not decreased, risk of drug interactions due to accelerated metabolism of other medications.

c.There is an increased risk of drug interactions due to accelerated metabolism of other medications.

d.CYP450 induction can affect pharmacokinetics by altering metabolism of other medications that are substrates for these enzymes.

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Correct Answer is B

Explanation

First-pass metabolism refers to the metabolism of a drug by the liver before it reaches systemic circulation. Drugs that undergo extensive first-pass metabolism have a lower bioavailability when administered orally because a significant portion of the drug is metabolized before it reaches systemic circulation. Intravenous administration bypasses first-pass metabolism and delivers the drug directly into systemic circulation.

a. Oral administration would result in lower bioavailability due to first-pass metabolism.

c. Subcutaneous administration may also be subject to first-pass metabolism.

d. Intramuscular administration may also be subject to first-pass metabolism.

A. The client may require a higher dose of the medication B. The client may require a lower dose of the medication C. The client may require more frequent dosing of the medication D. The client’s renal function does not affect pharmacokinetics

Correct Answer is B

Explanation

Medications that are primarily excreted by the kidneys can accumulate in clients with renal impairment, potentially leading to toxicity.A client with renal impairment may require a lower dose of a medication that is primarily excreted by the kidneys to avoid accumulation and toxicity.

a.The client may require a lower, not higher, dose of the medication due to reduced renal excretion.

c.More frequent dosing may not be necessary if an appropriate dose is administered.

d.The client’s renal function can affect pharmacokinetics by altering excretion of medications that are primarily eliminated by the kidneys.

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A nurse is preparing to administer a medication that induces CYP450 enzymes.What should be considered when administering this drug with other medications?

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Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer a medication that undergoes extensive first-pass metabolism. What route of administration should be used?

Correct Answer is B

Explanation

A nurse is preparing to administer a medication that is primarily excreted by the kidneys.What should be considered when administering this drug to a client with renal impairment?

Correct Answer is B

Explanation

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