A nurse is preparing to administer a medication that induces CYP450 enzymes.What should be considered when administering this drug with other medications?
There is an increased risk of drug interactions
There is a decreased risk of drug interactions
There is no risk of drug interactions
CYP450 induction does not affect pharmacokinetics
The Correct Answer is A
CYP450 enzymes are responsible for metabolizing many medications.Induction of CYP450 enzymes can increase their activity and accelerate metabolism of other medications that are substrates for these enzymes, potentially reducing their therapeutic effect and increasing the risk of drug interactions.
b.There is an increased, not decreased, risk of drug interactions due to accelerated metabolism of other medications.
c.There is an increased risk of drug interactions due to accelerated metabolism of other medications.
d.CYP450 induction can affect pharmacokinetics by altering metabolism of other medications that are substrates for these enzymes.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
CYP450 enzymes are responsible for metabolizing many medications.Induction of CYP450 enzymes can increase their activity and accelerate metabolism of other medications that are substrates for these enzymes, potentially reducing their therapeutic effect and increasing the risk of drug interactions.
b.There is an increased, not decreased, risk of drug interactions due to accelerated metabolism of other medications.
c.There is an increased risk of drug interactions due to accelerated metabolism of other medications.
d.CYP450 induction can affect pharmacokinetics by altering metabolism of other medications that are substrates for these enzymes.
Correct Answer is A
Explanation
Medications that are highly protein bound bind to plasma proteins such as albumin, reducing their free fraction and potentially reducing their therapeutic effect.A client with hypoalbuminemia may have an increased free fraction of a highly protein-bound medication due to reduced protein binding, potentially increasing its therapeutic effect.
b.The client may have an increased, not decreased, free fraction of the drug due to reduced protein binding.
c.An increased volume of distribution may occur if protein binding is reduced, but this is not directly related to hypoalbuminemia.
d.The client’s albumin levels can affect pharmacokinetics by altering protein binding of highly protein-bound medications.
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