A nurse is preparing to administer a prodrug that requires activation by hepatic enzymes.What should be considered when administering this drug?

The drug will have increased efficacy if given with food

The drug will have decreased efficacy if given with food

The drug will have decreased efficacy if given with an enzyme inducer

The drug will have increased efficacy if given with an enzyme inducer

Answer and Explanation

The Correct Answer is A

A prodrug is an inactive compound that requires conversion into its active form by metabolic processes such as hepatic enzyme activation.Giving a prodrug with an enzyme inducer can increase the activity of the hepatic enzymes responsible for converting the prodrug into its active form, potentially increasing its efficacy.

a.Giving the drug with food may affect its absorption but does not directly affect its activation by hepatic enzymes.

b.Giving the drug with food may affect its absorption but does not directly affect its activation by hepatic enzymes.

c.Giving the drug with an enzyme inducer, not an enzyme inhibitor, can increase its efficacy by increasing hepatic enzyme activity.

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Correct Answer is B

Explanation

Weakly acidic medications are more readily absorbed in an acidic environment because they are more likely to be in their non-ionized, lipid-soluble form which can easily cross cell membranes and enter systemic circulation. An elevated gastric pH due to antacid use can reduce absorption of weakly acidic medications by increasing ionization and reducing lipid solubility.

a. The medication will have decreased, not increased, absorption in an alkaline environment due to increased ionization.

c. The antacid can affect absorption by altering gastric pH and increasing ionization of weakly acidic medications.

d. The antacid can affect absorption but does not directly affect excretion of weakly acidic medications.

A. Administer the medication as prescribed. B. Hold the medication and notify the provider. C. Administer half the dose of the medication. D. Administer the medication with food or milk.

Correct Answer is B

Explanation

A medication with a narrow therapeutic index has a small margin of safety between its therapeutic and toxic doses. The nurse should hold the medication and notify the provider to ensure that the client’s drug levels are within the therapeutic range and to avoid potential toxicity.

a. Administering the medication as prescribed could result in toxicity if the client’s drug levels are not within the therapeutic range.

c. Administering half the dose of the medication is not appropriate without consulting the provider and monitoring the client’s drug levels.

d. Administering the medication with food or milk may affect its absorption but does not prevent potential toxicity.

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A nurse is preparing to administer a prodrug that requires activation by hepatic enzymes.What should be considered when administering this drug?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer a weakly acidic medication to a client with an elevated gastric pH due to antacid use. What should the nurse consider?

Correct Answer is B

Explanation

A nurse is preparing to administer a medication that has a narrow therapeutic index. What action should the nurse take?

Correct Answer is B

Explanation

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