A nurse is preparing to administer a weakly acidic medication to a client with an elevated gastric pH due to antacid use. What should the nurse consider?

The medication will have increased absorption in an alkaline environment.

The medication will have decreased absorption in an alkaline environment.

The antacid will have no effect on absorption of the weakly acidic medication.

The antacid will increase excretion of the weakly acidic medication.

Answer and Explanation

The Correct Answer is B

Weakly acidic medications are more readily absorbed in an acidic environment because they are more likely to be in their non-ionized, lipid-soluble form which can easily cross cell membranes and enter systemic circulation. An elevated gastric pH due to antacid use can reduce absorption of weakly acidic medications by increasing ionization and reducing lipid solubility.

a. The medication will have decreased, not increased, absorption in an alkaline environment due to increased ionization.

c. The antacid can affect absorption by altering gastric pH and increasing ionization of weakly acidic medications.

d. The antacid can affect absorption but does not directly affect excretion of weakly acidic medications.

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Correct Answer is A

Explanation

CYP450 enzymes are responsible for metabolizing many medications.Induction of CYP450 enzymes can increase their activity and accelerate metabolism of other medications that are substrates for these enzymes, potentially reducing their therapeutic effect and increasing the risk of drug interactions.

b.There is an increased, not decreased, risk of drug interactions due to accelerated metabolism of other medications.

c.There is an increased risk of drug interactions due to accelerated metabolism of other medications.

d.CYP450 induction can affect pharmacokinetics by altering metabolism of other medications that are substrates for these enzymes.

A. The drug will have a shorter half-life B. The drug will have a longer half-life C. The drug will have increased bioavailability D. The drug will have decreased bioavailability

Correct Answer is B

Explanation

Enterohepatic recirculation refers to the process by which a drug or its metabolites are excreted into bile, reabsorbed from the intestines, and returned to the liver.Medications that undergo enterohepatic recirculation can have a longer half-life due to repeated reabsorption and recirculation.

a.The drug will have a longer, not shorter, half-life due to repeated reabsorption and recirculation.

c.Enterohepatic recirculation can affect half-life but does not directly affect bioavailability.

d.Enterohepatic recirculation can affect half-life but does not directly affect bioavailability.

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A nurse is preparing to administer a weakly acidic medication to a client with an elevated gastric pH due to antacid use. What should the nurse consider?

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Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer a medication that induces CYP450 enzymes.What should be considered when administering this drug with other medications?

Correct Answer is A

Explanation

A nurse is preparing to administer a medication that undergoes enterohepatic recirculation.What should be considered when administering this drug?

Correct Answer is B

Explanation

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