A nurse is preparing to administer a medication that inhibits P-glycoprotein.What should be considered when administering this drug with other medications?

There is an increased risk of drug interactions

There is a decreased risk of drug interactions

There is no risk of drug interactions

P-glycoprotein inhibition does not affect pharmacokinetics

Answer and Explanation

The Correct Answer is A

P-glycoprotein is a membrane protein that pumps certain drugs out of cells and can affect their absorption, distribution, and elimination. Inhibition of P-glycoprotein can increase the concentration of other medications that are substrates for this protein, potentially increasing their therapeutic effect and the risk of drug interactions.

b. There is an increased, not decreased, risk of drug interactions due to increased concentration of other medications that are substrates for P-glycoprotein.

c. There is an increased risk of drug interactions due to increased concentration of other medications that are substrates for P-glycoprotein.

d. P-glycoprotein inhibition can affect pharmacokinetics by altering absorption, distribution, and elimination of other medications that are substrates for this protein.

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Correct Answer is A

Explanation

A prodrug is an inactive compound that requires conversion into its active form by metabolic processes such as hepatic enzyme activation.Giving a prodrug with an enzyme inducer can increase the activity of the hepatic enzymes responsible for converting the prodrug into its active form, potentially increasing its efficacy.

a.Giving the drug with food may affect its absorption but does not directly affect its activation by hepatic enzymes.

b.Giving the drug with food may affect its absorption but does not directly affect its activation by hepatic enzymes.

c.Giving the drug with an enzyme inducer, not an enzyme inhibitor, can increase its efficacy by increasing hepatic enzyme activity.

A. There is an increased risk of drug interactions B. There is a decreased risk of drug interactions C. There is no risk of drug interactions D. CYP450 induction does not affect pharmacokinetics

Correct Answer is A

Explanation

CYP450 enzymes are responsible for metabolizing many medications.Induction of CYP450 enzymes can increase their activity and accelerate metabolism of other medications that are substrates for these enzymes, potentially reducing their therapeutic effect and increasing the risk of drug interactions.

b.There is an increased, not decreased, risk of drug interactions due to accelerated metabolism of other medications.

c.There is an increased risk of drug interactions due to accelerated metabolism of other medications.

d.CYP450 induction can affect pharmacokinetics by altering metabolism of other medications that are substrates for these enzymes.

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A nurse is preparing to administer a medication that inhibits P-glycoprotein.What should be considered when administering this drug with other medications?

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Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer a prodrug that requires activation by hepatic enzymes.What should be considered when administering this drug?

Correct Answer is A

Explanation

A nurse is preparing to administer a medication that induces CYP450 enzymes.What should be considered when administering this drug with other medications?

Correct Answer is A

Explanation

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