A nurse is preparing to administer a medication that inhibits P-glycoprotein.What should be considered when administering this drug with other medications?

There is an increased risk of drug interactions

There is a decreased risk of drug interactions

There is no risk of drug interactions

P-glycoprotein inhibition does not affect pharmacokinetics

Answer and Explanation

The Correct Answer is A

P-glycoprotein is a membrane protein that pumps certain drugs out of cells and can affect their absorption, distribution, and elimination. Inhibition of P-glycoprotein can increase the concentration of other medications that are substrates for this protein, potentially increasing their therapeutic effect and the risk of drug interactions.

b. There is an increased, not decreased, risk of drug interactions due to increased concentration of other medications that are substrates for P-glycoprotein.

c. There is an increased risk of drug interactions due to increased concentration of other medications that are substrates for P-glycoprotein.

d. P-glycoprotein inhibition can affect pharmacokinetics by altering absorption, distribution, and elimination of other medications that are substrates for this protein.

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Correct Answer is B

Explanation

A medication with a narrow therapeutic index has a small margin of safety between its therapeutic and toxic doses. The nurse should hold the medication and notify the provider to ensure that the client’s drug levels are within the therapeutic range and to avoid potential toxicity.

a. Administering the medication as prescribed could result in toxicity if the client’s drug levels are not within the therapeutic range.

c. Administering half the dose of the medication is not appropriate without consulting the provider and monitoring the client’s drug levels.

d. Administering the medication with food or milk may affect its absorption but does not prevent potential toxicity.

A. The client may require a higher dose of the medication. B. The client may require a lower dose of the medication. C. The client may require more frequent dosing of the medication. D. The client’s body fat percentage does not affect pharmacokinetics.

Correct Answer is A

Explanation

Lipophilic medications are soluble in fat and can accumulate in adipose tissue, reducing their concentration in plasma and potentially reducing their therapeutic effect. A client with a high body fat percentage may require a higher dose of a lipophilic medication to achieve therapeutic levels.

b. The client may require a higher, not lower, dose of the medication due to accumulation in adipose tissue.

c. More frequent dosing may not be necessary if an appropriate dose is administered.

d. The client’s body fat percentage can affect pharmacokinetics by altering distribution of lipophilic medications.

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A nurse is preparing to administer a medication that inhibits P-glycoprotein.What should be considered when administering this drug with other medications?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer a medication that has a narrow therapeutic index. What action should the nurse take?

Correct Answer is B

Explanation

A nurse is preparing to administer a lipophilic medication to a client with a high body fat percentage. What should the nurse consider?

Correct Answer is A

Explanation

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