A nurse is providing an in-service about nonsteroidal anti-inflammatory drugs (NSAIDs) to the unit.
Which of the following is considered a second-generation NSAID?

Choice A rationale

Antagonistic reactions occur when one drug interferes with the action of another, decreasing its effectiveness. This is not applicable in this case as aspirin and alcohol together increase the risk of bleeding rather than opposing each other's actions.

Choice B rationale

Synergistic reactions happen when two drugs enhance each other's effects. Aspirin and alcohol together can indeed increase the risk of gastrointestinal bleeding, but this is not referred to as a synergistic reaction.

Choice C rationale

Additive reactions occur when two drugs with similar effects add up to a greater effect. Aspirin and alcohol both increase the risk of bleeding, and their combined effect leads to gastrointestinal bleeding.

Choice D rationale

Neutral reactions imply that the drugs do not interact and have no combined effect, which is incorrect here as the combination of aspirin and alcohol leads to an increased risk of GI bleeding.

Choice A rationale

Rotating injection sites helps prevent lipohypertrophy, which is the thickening of subcutaneous tissue due to repeated insulin injections at the same site.

Choice B rationale

Performing injections at the same location every time increases the risk of lipohypertrophy, leading to poor insulin absorption and erratic glucose control.

Choice C rationale

Administering an additional dose of insulin as needed does not address the issue of lipohypertrophy and can lead to hypoglycemia if not carefully monitored.

Choice D rationale

Insulin is a peptide hormone that must be injected. Taking it orally is ineffective as it would be broken down in the digestive system.