A nurse is providing an in-service about nonsteroidal anti-inflammatory drugs (NSAIDs) to the unit.
Which of the following is considered a second-generation NSAID?

Choice A rationale

Stevens-Johnson syndrome is a severe and potentially life-threatening reaction to medications, including lamotrigine. It is characterized by widespread skin necrosis and mucous membrane involvement. Hospitalization is required to manage the symptoms and prevent complications such as infections and organ failure.

Choice A rationale

Celecoxib does not inhibit the histamine response. Histamine is involved in allergic reactions, and celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that targets specific enzymes involved in inflammation.

Choice B rationale

Celecoxib specifically inhibits COX-2, an enzyme involved in the inflammation pathway. This selective inhibition helps reduce inflammation and pain without significantly affecting COX-1, which is protective for the stomach lining.

Choice C rationale

COX-1 is not the primary target of celecoxib. Inhibition of COX-1 can lead to gastrointestinal side effects, which celecoxib aims to minimize by selectively inhibiting COX-2 instead.

Choice D rationale

Celecoxib does not inhibit beta receptors. Beta receptors are involved in cardiovascular responses, and beta blockers are used for conditions like hypertension, not inflammation.