A nurse is reviewing pharmacokinetic principles. Which of the following factors most significantly affects the distribution of drugs in the body?
The Cytochrome P-450 Enzyme System
Renal function
Gastric pH
Blood flow
The Correct Answer is D
A. The Cytochrome P-450 Enzyme System: This system plays a major role in drug metabolism, particularly in the liver, but it does not significantly affect drug distribution. Its primary influence is on the biotransformation of drugs into active or inactive metabolites.
B. Renal function: Renal function primarily affects drug excretion. Impaired kidney function can lead to drug accumulation and toxicity but has a minimal direct effect on the distribution of drugs throughout tissues and organs.
C. Gastric pH: Gastric pH influences drug absorption in the gastrointestinal tract, especially for pH-sensitive drugs. However, it plays little to no role in the actual distribution of the drug once it enters systemic circulation.
D. Blood flow: Blood flow is the most significant factor affecting drug distribution. Highly perfused organs like the brain, liver, and kidneys receive drugs more quickly and in higher concentrations than poorly perfused tissues, influencing the onset and intensity of drug action.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is ["30"]
Explanation
Given quantity = 6 teaspoons
Desired unit = mL (milliliters)
Convert from teaspoons to milliliters
1 teaspoon ≈ 5 mL
6 teaspoons × 5 mL/teaspoon
= 30 mL
Correct Answer is B
Explanation
A. "I should avoid antitussives if I have a productive cough with mucus.": Antitussives can inhibit the body’s ability to clear mucus when coughing is suppressed. In the case of a productive cough, clearing secretions is essential to prevent airway obstruction and secondary infections.
B. "Antitussives are helpful in clearing mucus from my lungs during a productive cough.": Antitussives reduce the cough reflex and do not aid in mucus clearance. Their use during a productive cough can lead to mucus retention, worsening congestion and increasing the risk of complications such as pneumonia.
C. "Using antitussives for a productive cough can lead to mucus buildup in my airways.": Suppressing a productive cough prevents the expulsion of mucus, which can accumulate in the lungs. This can impair gas exchange and create an environment for bacterial growth.
D. "Antitussives are used to suppress a dry, nonproductive cough.": These medications are most appropriate when there is no mucus to expel. They help reduce the frequency and intensity of dry coughing, especially when it interferes with sleep or comfort.
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