A nurse is teaching a client who has chronic tophaceous gout about his new prescription for allopurinol. The nurse should explain that the purpose of this medication is to reduce blood levels of which of the following substances?
Interleukin 1
Uric acid
Potassium
Chloride
The Correct Answer is B
Choice A reason: Interleukin 1 is a pro-inflammatory cytokine involved in gout’s acute inflammatory response, not directly targeted by allopurinol. Allopurinol reduces uric acid production, preventing crystal formation, not cytokine levels. This choice is incorrect, as it misaligns with the medication’s mechanism of action in chronic gout management.
Choice B reason: Allopurinol inhibits xanthine oxidase, reducing uric acid production, which is elevated in chronic tophaceous gout. Lowering uric acid levels prevents urate crystal formation in joints, reducing tophi and gout attacks. This is the correct explanation, as allopurinol directly targets hyperuricemia, the root cause of gout pathology.
Choice C reason: Potassium levels are unrelated to gout or allopurinol’s action. Allopurinol does not affect electrolyte balance but focuses on purine metabolism to lower uric acid. This choice is incorrect, as potassium is not involved in gout’s pathophysiology or the therapeutic effect of allopurinol.
Choice D reason: Chloride is an electrolyte not associated with gout or allopurinol’s mechanism. Allopurinol’s role is specific to uric acid reduction, not chloride homeostasis. This choice is irrelevant, as chloride levels do not contribute to gout or require modification in chronic tophaceous gout management.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A reason: Plaster of Paris casts must be kept dry, as water weakens the material, causing breakdown or skin maceration. Covering the cast with a waterproof barrier during showering is essential. This instruction is incorrect, as it risks cast damage and skin infections, which could complicate recovery.
Choice B reason: Applying ice after walking may reduce swelling, but it is not a standard instruction for a walking cast unless edema is present. Ice can dampen the cast, risking structural integrity. Monitoring neurovascular status is more critical, making this less essential compared to reporting symptoms.
Choice C reason: A musty odor is not normal and may indicate moisture, skin breakdown, or infection beneath the cast. Patients should report odors, as they suggest complications requiring evaluation. This instruction is incorrect, as it dismisses a potential sign of serious issues like bacterial growth or tissue damage.
Choice D reason: Reporting numbness or pain in the toes is critical, as these symptoms may indicate neurovascular compromise, such as compartment syndrome or nerve compression from a tight cast. Early reporting ensures timely intervention to prevent permanent damage, making this a key instruction for safe cast management and recovery.
Correct Answer is B
Explanation
Choice A reason: Pitting edema of the hands and fingers is not a typical SLE finding. It may occur in conditions like heart failure or nephrotic syndrome, but SLE more commonly causes joint swelling or effusions due to synovitis. Expecting edema misdirects assessment, potentially overlooking SLE’s hallmark cutaneous and musculoskeletal symptoms critical for diagnosis.
Choice B reason: A dry, red rash across the nose and cheeks, known as a malar or butterfly rash, is a hallmark of SLE, present in 30-60% of patients. This photosensitive rash results from autoimmune-mediated cutaneous inflammation, aiding diagnosis. Its distinct pattern distinguishes SLE from other dermatologic conditions, guiding targeted treatment.
Choice C reason: A grey, non-purpuric papular rash is not characteristic of SLE. SLE rashes are typically erythematous and photosensitive, like the malar rash, or discoid with scaling. A grey papular rash suggests conditions like lichen planus, not SLE, and including it risks misdiagnosis, delaying appropriate immunosuppressive therapy.
Choice D reason: Subcutaneous nodules on the ulnar arm are more typical of rheumatoid arthritis, not SLE. SLE may cause cutaneous lupus lesions, but nodules are rare. Expecting this finding could lead to confusion with other connective tissue diseases, misguiding assessment and delaying SLE-specific treatments like hydroxychloroquine
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