A patient asks a nurse why a friend who is taking the same drug responds differently to that drug. The nurse knows that the most common variation in drug response is due to differences in each patient’s:
Psychosocial response
Drug receptor sites
Metabolism of drugs
Hypersensitivity potential
The Correct Answer is C
Choice A Reason:
Psychosocial factors, such as stress, beliefs, and expectations, can influence drug response to some extent. However, they are not the primary reason for the most common variations in drug response. These factors might affect how a patient perceives the effectiveness of a drug, but they do not significantly alter the pharmacokinetics or pharmacodynamics of the drug itself.
Choice B Reason:
Drug receptor sites can vary between individuals, affecting how well a drug binds and exerts its effect. While this can contribute to differences in drug response, it is not the most common cause. Variations in receptor sites are often due to genetic differences, which can influence the efficacy and potency of a drug.
Choice C Reason:
This is the correct answer. The metabolism of drugs is the most common cause of variation in drug response among individuals. Differences in metabolic rates can be attributed to genetic factors, age, liver function, and the presence of other medications. These factors affect how quickly a drug is broken down and eliminated from the body, leading to variations in drug levels and responses.
Choice D Reason:
Hypersensitivity potential refers to the likelihood of an individual having an allergic reaction to a drug. While this can cause significant differences in drug response, it is not the most common reason for variations. Hypersensitivity reactions are relatively rare compared to metabolic differences.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Choice A: Alpha 1 Agonist and Alpha 2 Antagonist Increase Blood Pressure
Alpha 1 receptors are primarily located on the smooth muscles of blood vessels. When activated by an agonist, these receptors cause vasoconstriction, which increases blood pressure. On the other hand, alpha 2 receptors are found on presynaptic nerve terminals and act to inhibit the release of norepinephrine. An antagonist at alpha 2 receptors would prevent this inhibition, leading to increased norepinephrine release, further promoting vasoconstriction and increasing blood pressure. Therefore, the combination of an alpha 1 agonist and an alpha 2 antagonist would synergistically increase blood pressure.
Choice B: Alpha 1 Agonist and Alpha 2 Agonist Decrease Blood Pressure
Alpha 1 agonists increase blood pressure by causing vasoconstriction. Alpha 2 agonists, however, decrease blood pressure by inhibiting norepinephrine release, leading to vasodilation. Therefore, this combination would not decrease blood pressure as the effects of the alpha 1 agonist would counteract the effects of the alpha 2 agonist.
Choice C: Alpha 1 and Alpha 2 Agonist Increase Blood Pressure
While alpha 1 agonists increase blood pressure through vasoconstriction, alpha 2 agonists actually decrease blood pressure by reducing norepinephrine release. Therefore, this statement is incorrect as the combined effect would not result in an increase in blood pressure.
Choice D: Alpha 1 Antagonist and Alpha 2 Agonist Decrease Blood Pressure
Alpha 1 antagonists block the vasoconstrictive action of alpha 1 receptors, leading to vasodilation and a decrease in blood pressure. Alpha 2 agonists also decrease blood pressure by inhibiting norepinephrine release. Therefore, this combination would indeed decrease blood pressure, making this statement partially correct but not the best answer compared to choice A.
Correct Answer is C
Explanation
Choice A Reason:
An idiosyncratic effect is an unusual or unexpected reaction to a drug that is not related to the dose and is not a common side effect. These reactions are often due to genetic differences in metabolism or immune response. In this case, shortness of breath is a known reaction for some patients taking the drug, so it is not considered idiosyncratic.
Choice B Reason:
A teratogenic effect refers to a drug’s potential to cause developmental abnormalities in a fetus when taken by a pregnant woman. Since the patient is experiencing shortness of breath, which is a known reaction to the drug, this choice is not relevant to the situation.
Choice C Reason:
This is the correct answer. A side effect is a secondary, typically undesirable effect of a drug or medical treatment. Since the nurse found that shortness of breath is a known reaction for some patients taking the drug, it is classified as a side effect. The nurse should report this to the provider to ensure proper management and monitoring.
Choice D Reason:
The symptom of shortness of breath is related to the medication administration, as confirmed by the drug administration manual. Therefore, this choice is incorrect. The nurse must report the side effect to the provider for appropriate action.
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