A patient asks a nurse why a friend who is taking the same drug responds differently to that drug. The nurse knows that the most common variation in drug response is due to differences in each patient’s:
Psychosocial response
Drug receptor sites
Metabolism of drugs
Hypersensitivity potential
The Correct Answer is C
Choice A Reason:
Psychosocial factors, such as stress, beliefs, and expectations, can influence drug response to some extent. However, they are not the primary reason for the most common variations in drug response. These factors might affect how a patient perceives the effectiveness of a drug, but they do not significantly alter the pharmacokinetics or pharmacodynamics of the drug itself.
Choice B Reason:
Drug receptor sites can vary between individuals, affecting how well a drug binds and exerts its effect. While this can contribute to differences in drug response, it is not the most common cause. Variations in receptor sites are often due to genetic differences, which can influence the efficacy and potency of a drug.
Choice C Reason:
This is the correct answer. The metabolism of drugs is the most common cause of variation in drug response among individuals. Differences in metabolic rates can be attributed to genetic factors, age, liver function, and the presence of other medications. These factors affect how quickly a drug is broken down and eliminated from the body, leading to variations in drug levels and responses.
Choice D Reason:
Hypersensitivity potential refers to the likelihood of an individual having an allergic reaction to a drug. While this can cause significant differences in drug response, it is not the most common reason for variations. Hypersensitivity reactions are relatively rare compared to metabolic differences.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A Reason:
Tertiary prevention involves measures taken to reduce the impact of an ongoing illness or injury that has lasting effects. This includes rehabilitation and efforts to prevent further complications or deterioration. Vaccination, however, is aimed at preventing the disease before it occurs, which does not align with the concept of tertiary prevention.
Choice B Reason:
Primary prevention refers to actions taken to prevent the onset of disease before it occurs. Vaccination is a classic example of primary prevention because it aims to protect individuals from contracting diseases by stimulating the immune system to recognize and fight specific pathogens. In this case, the meningococcal vaccine helps prevent meningitis, making it a primary preventive measure.
Choice C Reason:
Disease treatment involves managing and caring for a patient to combat a disease or condition. This includes interventions aimed at curing the disease, alleviating symptoms, or preventing complications. Vaccination does not fall under disease treatment because it is a preventive measure rather than a therapeutic one
Choice D Reason:
Secondary prevention focuses on early detection and prompt intervention to prevent the progression of a disease. This includes screening tests and early treatment of conditions to halt or slow their progression. Vaccination, however, is intended to prevent the disease from occurring in the first place, which is not the goal of secondary prevention.
Correct Answer is A
Explanation
Choice A: Metabolic Acid Deficit (Metabolic Alkalosis)
Vomiting or continuous nasogastric suctioning leads to the loss of gastric contents, which are rich in hydrochloric acid (HCl)1. This loss results in a decrease in the body’s acid levels, leading to a condition known as metabolic alkalosis2. Metabolic alkalosis is characterized by an increase in blood pH due to the loss of hydrogen ions (H+) and an increase in bicarbonate (HCO3-) levels. This condition can cause symptoms such as muscle twitching, hand tremors, and light-headedness.
Choice B: Carbonic Acid Excess (Respiratory Acidosis)
Carbonic acid excess, or respiratory acidosis, occurs when there is an accumulation of carbon dioxide (CO2) in the blood, leading to a decrease in blood pH3. This condition is typically caused by respiratory issues such as hypoventilation, chronic obstructive pulmonary disease (COPD), or severe asthma. It is not directly related to vomiting or nasogastric suctioning, which primarily affect the metabolic component of acid-base balance.
Choice C: Metabolic Acid Excess (Metabolic Acidosis)
Metabolic acidosis is characterized by a decrease in blood pH due to an accumulation of metabolic acids or a loss of bicarbonate. Common causes include renal failure, diabetic ketoacidosis, and severe diarrhea. Vomiting or nasogastric suctioning, which result in the loss of gastric acid, do not lead to metabolic acidosis but rather to metabolic alkalosis.
Choice D: Carbonic Acid Deficit (Respiratory Alkalosis)
Respiratory alkalosis occurs when there is a decrease in carbon dioxide levels in the blood, leading to an increase in blood pH. This condition is often caused by hyperventilation due to anxiety, fever, or high altitude. It is not related to the loss of gastric contents through vomiting or nasogastric suctioning, which primarily affect the metabolic component of acid-base balance.
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