A patient has been given a prescription for levodopa-carbidopa for a new diagnosis of Parkinson's disease. The patient asks the nurse, "Why are there two drugs in this pill?" The nurse's best response reflects which fact?
Carbidopa prevents the breakdown of levodopa in the periphery.
Carbidopa is the biologic precursor of dopamine and can penetrate into the central nervous system.
Carbidopa allows for larger doses of levodopa to be given.
There are concerns about drug-food interactions with levodopa therapy that do not exist with the combination therapy.
The Correct Answer is A
A. Carbidopa prevents the breakdown of levodopa in the periphery, specifically in the gastrointestinal tract and peripheral tissues, allowing more levodopa to reach the brain and be converted to dopamine. This enhances the effectiveness of levodopa therapy in managing the symptoms of Parkinson's disease.
B. Carbidopa is not the biologic precursor of dopamine. It is a peripheral decarboxylase inhibitor that does not cross the blood-brain barrier.
C. Carbidopa does not directly allow for larger doses of levodopa to be given. However, by
inhibiting the peripheral breakdown of levodopa, it enhances the availability of levodopa to the central nervous system, potentially improving therapeutic efficacy.
D. While levodopa-carbidopa combination therapy may have fewer drug-food interactions compared to levodopa alone, the primary reason for combining these medications is to enhance the effectiveness of levodopa by preventing its peripheral breakdown.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
A. Tachycardia is not typically associated with cholinergic drug effects. Cholinergic stimulation tends to slow down the heart rate rather than increase it.
B. Palpitations may occur with certain cardiac arrhythmias or in response to sympathetic stimulation, but they are not typically associated with cholinergic drug effects.
C. Cholinergic drugs are more likely to cause vasodilation rather than vasoconstriction.
Therefore, vasoconstriction is not a common cardiovascular effect of cholinergic drug therapy.
D. Bradycardia is a common cardiovascular effect of cholinergic drug therapy. Cholinergic stimulation slows down the heart rate by increasing parasympathetic activity, particularly at the
sinoatrial (SA) node. Therefore, bradycardia is the cardiovascular effect that nurses should monitor for when administering cholinergic drugs.
Correct Answer is D
Explanation
A. Do slow position changes to avoid falls from lowering blood pressure: This is not the priority teaching point for an anticholinergic medication. While some anticholinergics can cause orthostatic hypotension, the risk of urinary retention is a more significant concern.
B. If you feel short of breath, use a rescue inhaler: This instruction is unrelated to the use of anticholinergic medication and may be more relevant for patients with emphysema.
C. "If possible, try to avoid rooms that are cold.": Avoiding cold rooms is not directly related to the use of anticholinergic medication. The priority teaching point should address potential adverse effects specific to the medication.
D. "Make sure to seek care immediately if you're not able to urinate.": Anticholinergic medications can exacerbate urinary retention, particularly in older adults with benign prostatic hyperplasia. It's crucial for the patient to understand the importance of seeking medical attention if they experience difficulty urinating.
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