A patient with suspected Paget's disease undergoes a bone biopsy. What is the primary purpose of the bone biopsy in diagnosing this condition?
To assess calcium levels in the bone
To confirm the presence of bone tumors
To evaluate bone density and strength
To examine bone tissue for characteristic changes
The Correct Answer is D
The primary purpose of a bone biopsy in diagnosing Paget's disease is to examine bone tissue for characteristic changes that confirm the diagnosis. Microscopic examination of the bone tissue can reveal the disorganized bone remodeling and other characteristic features of the condition.
a. To assess calcium levels in the bone: Bone biopsies are not performed to assess calcium levels in the bone. Other diagnostic tests, such as blood tests, are used for that purpose.
b. To confirm the presence of bone tumors: Paget's disease is not a bone tumor, and the biopsy is not performed to confirm the presence of tumors. The biopsy confirms the specific bone changes associated with the condition.
c. To evaluate bone density and strength: Bone biopsies do not directly evaluate bone density and strength. Other imaging modalities, such as X-rays and DXA scans, are used for assessing bone density.
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Correct Answer is C
Explanation
Osteoclasts are the primary cell type responsible for bone resorption in Paget's disease. These cells become overactive, leading to excessive bone breakdown, which is a hallmark of the condition.
a. Osteocytes: Osteocytes are mature bone cells embedded in the bone matrix. While they play a role in maintaining bone health, they are not directly responsible for bone resorption.
b. Osteoblasts: Osteoblasts are bone-forming cells. In Paget's disease, they attempt to repair the resorbed bone but their activity is disordered, leading to structurally abnormal bone formation.
d. Osteoprogenitor cells: Osteoprogenitor cells are undifferentiated cells that can differentiate into osteoblasts. They are not directly involved in the increased bone resorption seen in Paget's disease.
Correct Answer is C
Explanation
Paget's disease is a metabolic bone disorder that involves abnormal bone remodeling, leading to areas of increased bone density and disorganized bone formation. It is not a genetic disorder, autoimmune disease, or neurological disorder.
a. A genetic disorder characterized by abnormal bone density: While Paget's disease has a genetic component, it is not solely a genetic disorder. The condition involves both genetic and environmental factors.
b. An autoimmune disease affecting the joints and connective tissues: Paget's disease is not an autoimmune disease. It primarily affects bone structures, not joints and connective tissues.
d. A degenerative neurological disorder causing muscle weakness: Paget's disease is not a neurological disorder. It does not directly affect the nervous system or cause muscle weakness.
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