A patient with suspected Paget's disease undergoes a bone biopsy. What is the primary purpose of the bone biopsy in diagnosing this condition?
To assess calcium levels in the bone
To confirm the presence of bone tumors
To evaluate bone density and strength
To examine bone tissue for characteristic changes
The Correct Answer is D
The primary purpose of a bone biopsy in diagnosing Paget's disease is to examine bone tissue for characteristic changes that confirm the diagnosis. Microscopic examination of the bone tissue can reveal the disorganized bone remodeling and other characteristic features of the condition.
a. To assess calcium levels in the bone: Bone biopsies are not performed to assess calcium levels in the bone. Other diagnostic tests, such as blood tests, are used for that purpose.
b. To confirm the presence of bone tumors: Paget's disease is not a bone tumor, and the biopsy is not performed to confirm the presence of tumors. The biopsy confirms the specific bone changes associated with the condition.
c. To evaluate bone density and strength: Bone biopsies do not directly evaluate bone density and strength. Other imaging modalities, such as X-rays and DXA scans, are used for assessing bone density.
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Correct Answer is C
Explanation
X-ray imaging is commonly used to confirm the diagnosis of Paget's disease. X-rays can show characteristic bone changes, such as bone enlargement, thickening, and deformities, which are indicative of Paget's disease.
a. Bone density scan: While bone density scans may be useful to assess bone health in other conditions, they are not the primary diagnostic tool for Paget's disease. X-rays are preferred.
b. Magnetic resonance imaging (MRI): MRI may provide detailed images of bones and surrounding soft tissues, but it is not the first-line diagnostic test for Paget's disease. X-rays are more commonly used.
d. Blood glucose test: A blood glucose test is used to diagnose and monitor diabetes, not Paget's disease. These conditions are unrelated.
Correct Answer is C
Explanation
Bisphosphonates are commonly used as the first-line treatment for Paget's disease. They work by slowing down bone resorption and promoting more balanced bone remodeling, helping to control the excessive bone turnover characteristic of the condition.
a. Calcium supplements: While calcium supplements are essential for overall bone health, they are not the first-line treatment for Paget's disease. Bisphosphonates specifically target the abnormal bone remodeling associated with the condition.
b. Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs may help manage pain and inflammation associated with Paget's disease, but they do not directly address the underlying bone remodeling abnormalities. Bisphosphonates are more effective in treating the condition.
d. Vitamin D supplements: Vitamin D is necessary for calcium absorption and bone health, but it is not the primary treatment for Paget's disease. Bisphosphonates are the mainstay of therapy.
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