A patient with suspected Paget's disease undergoes a bone biopsy. What is the primary purpose of the bone biopsy in diagnosing this condition?
To assess calcium levels in the bone
To confirm the presence of bone tumors
To evaluate bone density and strength
To examine bone tissue for characteristic changes
The Correct Answer is D
The primary purpose of a bone biopsy in diagnosing Paget's disease is to examine bone tissue for characteristic changes that confirm the diagnosis. Microscopic examination of the bone tissue can reveal the disorganized bone remodeling and other characteristic features of the condition.
a. To assess calcium levels in the bone: Bone biopsies are not performed to assess calcium levels in the bone. Other diagnostic tests, such as blood tests, are used for that purpose.
b. To confirm the presence of bone tumors: Paget's disease is not a bone tumor, and the biopsy is not performed to confirm the presence of tumors. The biopsy confirms the specific bone changes associated with the condition.
c. To evaluate bone density and strength: Bone biopsies do not directly evaluate bone density and strength. Other imaging modalities, such as X-rays and DXA scans, are used for assessing bone density.
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Correct Answer is B
Explanation
A bone scan is the most appropriate diagnostic test for confirming the diagnosis of Paget's disease. It can reveal increased bone turnover and abnormal bone remodeling patterns characteristic of the condition. The bone scan can show "hot spots" of increased uptake in affected bones.
a. Complete blood count (CBC): While a CBC can be useful in ruling out other conditions, it does not directly diagnose Paget's disease. Specific bone imaging is required for confirmation.
c. Liver function tests (LFTs): Liver function tests are not used to diagnose Paget's disease. The condition primarily affects bone structures, and liver involvement is not a primary concern.
d. Magnetic resonance imaging (MRI): While an MRI can provide detailed images of bones and soft tissues, it may not be the initial choice for diagnosing Paget's disease. A bone scan is more specific to evaluate bone turnover and remodeling.
Correct Answer is D
Explanation
Paget's disease is most commonly observed in older adults, typically over the age of 40. It is more prevalent in the elderly population.
a. Children and adolescents: While Paget's disease can occur in younger individuals, it is much more common in older adults.
b. Young adults: Paget's disease is not commonly observed in young adults. It typically develops later in life.
c. Middle-aged adults: While Paget's disease can occur in middle-aged adults, it is more commonly seen in older adults.
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