Glyburide works by which of the following mechanisms?

Stimulating glucose uptake in the skeletal muscles.

Increasing the cells' sensitivity to insulin.

Stimulating the release of insulin from the pancreas.

Inhibiting the breakdown of carbohydrates in the intestines.

Answer and Explanation

The Correct Answer is C

Choice A rationale

Glyburide does not stimulate glucose uptake directly in skeletal muscles. Instead, it acts on pancreatic beta cells, affecting insulin release. Enhancing muscular glucose uptake occurs through insulin’s action downstream.

Choice B rationale

Glyburide does not primarily increase insulin sensitivity. Agents like metformin work to sensitize cells to insulin, but Glyburide functions by stimulating endogenous insulin release.

Choice C rationale

Glyburide stimulates insulin release from pancreatic beta cells by closing ATP-sensitive potassium channels, leading to calcium influx and insulin secretion. This increases circulating insulin, aiding glucose uptake and reducing blood glucose levels.

Choice D rationale

Glyburide does not inhibit carbohydrate breakdown in the intestines. Medications like alpha-glucosidase inhibitors target intestinal enzymes to slow carbohydrate digestion, unlike Glyburide’s pancreatic action.

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Correct Answer is ["A","D"]

Explanation

Choice A rationale

Using a urine filter ensures the recovery of passed stones for laboratory analysis, assisting in identifying stone composition and tailoring prevention strategies.

Choice B rationale

Calcium intake is essential for bone health and reducing oxalate absorption. Avoiding calcium increases oxalate availability, worsening stone formation.

Choice C rationale

Diuretic fluids like coffee promote dehydration and concentration of urine, increasing the risk of stone recurrence. Diuretics should be prescribed for specific stone types.

Choice D rationale

Maintaining hydration prevents urine concentration and the supersaturation of stone-forming crystals, which are primary risk factors for nephrolithiasis.

A. True. B. False.

Correct Answer is B

Explanation

Choice A rationale

Mixing insulin glargine and lispro in the same syringe is contraindicated due to their incompatible chemical formulations. Glargine’s acidic pH alters lispro’s effectiveness when mixed, impairing glycemic control. Separate administration preserves their individual pharmacokinetics and therapeutic actions.

Choice B rationale

Separate injections ensure each insulin maintains its unique action profile. Glargine provides basal control, while lispro manages rapid postprandial spikes. Their chemical incompatibility mandates separate administration, optimizing glycemic management and reducing potential adverse effects from mixed formulations.

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Glyburide works by which of the following mechanisms?

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Naxlex Comprehensive Predictor Exams

Which topic would the nurse include when teaching the patient ways to prevent the recurrence of kidney stones?

Correct Answer is ["A","D"]

Explanation

If both Insulin glargine (Lantus) and insulin lispro (Humalog) are due simultaneously, the nurse can mix the two insulins in the same syringe and administer them as one injection.

Correct Answer is B

Explanation

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