How are primary immunodeficiency disorders different from secondary immunodeficiency disorders?
Primary immunodeficiency disorders are acquired later in life, while secondary immunodeficiency disorders are present from birth.
Primary immunodeficiency disorders result from a genetic or inherited defect, while secondary immunodeficiency disorders are caused by external factors, such as infections or medications.
Primary immunodeficiency disorders primarily affect the skin and mucous membranes, while secondary immunodeficiency disorders primarily affect the respiratory system.
Primary immunodeficiency disorders are more common than secondary immunodeficiency disorders.
The Correct Answer is B
Explanation: The correct answer is b. Primary immunodeficiency disorders result from a genetic or inherited defect, while secondary immunodeficiency disorders are caused by external factors, such as infections or medications.
Incorrect choices:
a. Primary immunodeficiency disorders are present from birth and are usually genetic or inherited, while secondary immunodeficiency disorders can be acquired later in life due to external factors.
c. The manifestations and systems affected by primary and secondary immunodeficiency disorders can vary widely and are not limited to specific areas of the body.
d. Secondary immunodeficiency disorders are more common than primary immunodeficiency disorders, as they can be caused by various factors and are often associated with other medical conditions.
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Correct Answer is B
Explanation
Explanation: The correct answer is b. Common variable immunodeficiency (CVID). CVID is a primary immunodeficiency disorder characterized by a reduced level of immunoglobulins, particularly IgA, leading to an increased susceptibility to infections.
Incorrect choices:
a. Severe combined immunodeficiency (SCID) is a more severe immunodeficiency disorder that affects multiple components of the immune system, not specifically IgA levels.
c. DiGeorge syndrome is caused by a genetic abnormality and is characterized by a defect in the development of certain organs, including the thymus and parathyroid glands. It may result in immune system abnormalities but does not primarily involve IgA deficiency.
d. Wiskott-Aldrich syndrome is a rare X-linked genetic disorder that affects platelet function and immune system regulation but is not specifically associated with IgA deficiency.
Correct Answer is A
Explanation
Explanation: The correct answer is a. Severe combined immunodeficiency (SCID). SCID is a severe and rare primary immunodeficiency disorder characterized by the absence or severe impairment of both T and B cells, leading to a profound deficiency in cellular and humoral immunity.
Incorrect choices:
b. X-linked agammaglobulinemia (XLA) primarily affects B-cell function, resulting in a lack of mature B cells and low levels of immunoglobulins, but does not typically involve T-cell deficiency.
c. Wiskott-Aldrich syndrome affects platelet function and immune system regulation, but it is not characterized by a deficiency of both T and B cells.
d. Common variable immunodeficiency (CVID) is characterized by reduced levels of immunoglobulins, particularly IgG and IgA, but it does not typically lead to a complete deficiency of both T and B cells.
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