Many of the clinical manifestations for acute stress are attributed to activation of the sympathetic nervous system and are mediated by:

Norepinephrine

Cortisol

ACTH

Glucagon

Answer and Explanation

The Correct Answer is A

Choice A Reason:

Norepinephrine is a key neurotransmitter released by the sympathetic nervous system during the “fight-or-flight” response. It plays a crucial role in preparing the body to respond to stress by increasing heart rate, blood pressure, and blood flow to muscles, as well as dilating the airways. These physiological changes are essential for coping with acute stress.

Choice B Reason:

Cortisol is a hormone released by the adrenal glands in response to stress, but it is primarily associated with the hypothalamic-pituitary-adrenal (HPA) axis rather than the sympathetic nervous system. While cortisol contributes to the body’s overall stress response by increasing blood sugar levels and suppressing the immune system, it is not the primary mediator of the acute “fight-or-flight” response.

Choice C Reason:

ACTH (adrenocorticotropic hormone) is a hormone produced by the pituitary gland that stimulates the adrenal glands to release cortisol. It is part of the HPA axis and plays a role in the body’s long-term stress response, but it is not directly involved in the immediate activation of the sympathetic nervous system.

Choice D Reason:

Glucagon is a hormone produced by the pancreas that raises blood glucose levels by promoting the breakdown of glycogen to glucose in the liver. While it can be involved in the body’s response to stress by ensuring an adequate supply of glucose, it is not a primary mediator of the acute stress response mediated by the sympathetic nervous system.

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Correct Answer is ["A","C"]

Explanation

Choice A Reason:

Acidosis is indicated by a pH lower than the normal range of 7.35-7.45. In this case, the patient’s pH is 7.3, which confirms acidosis. Acidosis can be caused by either respiratory or metabolic factors, but the low pH alone confirms the presence of acidosis.

Choice B Reason:

Compensation refers to the body’s attempt to return the pH to normal by adjusting the levels of CO2 or HCO3-. In this case, the HCO3- level is within the normal range (22-26 mEq/L), indicating that there is no metabolic compensation occurring. Therefore, this choice is incorrect.

Choice C Reason:

Respiratory acidosis is indicated by an elevated PaCO2 level, which is higher than the normal range of 36-44 mmHg. The patient’s PaCO2 is 48 mmHg, suggesting that the acidosis is due to respiratory factors. This is consistent with the patient’s history of smoking and symptoms of respiratory distress.

Choice D Reason:

Alkalosis is indicated by a pH higher than the normal range of 7.35-7.45. Since the patient’s pH is 7.3, which is below the normal range, this indicates acidosis, not alkalosis. Therefore, this choice is incorrect.

Choice E Reason:

Metabolic acidosis is indicated by a low HCO3- level. In this case, the patient’s HCO3- level is within the normal range (25 mEq/L), indicating that the acidosis is not metabolic. Therefore, this choice is incorrect.

A. They indicate that a drug should not be given except in life-threatening circumstances. B. They provide detailed information about medications that can have teratogenic effects. C. They alert prescribers to measures to mitigate potential harm from side effects. D. They provide information about antidotes in the event that toxicity occurs.

Correct Answer is C

Explanation

Choice A Reason:

Boxed warnings, also known as black box warnings, are the strictest warnings put in the labeling of prescription drugs by the FDA when there is reasonable evidence of an association of a serious hazard with the drug. However, they do not necessarily indicate that a drug should only be given in life-threatening circumstances. Instead, they highlight the potential for serious or life-threatening risks and advise on how to use the drug safely.

Choice B Reason:

While some boxed warnings may include information about teratogenic effects (effects that can cause birth defects), this is not their primary purpose. Boxed warnings are broader and can apply to various serious risks, not just teratogenicity. Therefore, this choice is too narrow to be correct.

Choice C Reason:

This is the correct answer. Boxed warnings are designed to alert prescribers to serious or life-threatening risks associated with a drug and provide guidance on how to mitigate these risks. This can include recommendations for monitoring, dosage adjustments, or avoiding certain populations. The goal is to ensure that prescribers are fully aware of the risks and can take appropriate measures to minimize harm to patients.

Choice D Reason:

Boxed warnings do not typically provide information about antidotes for toxicity. While managing toxicity is an important aspect of drug safety, boxed warnings focus on alerting prescribers to serious risks and how to mitigate them, rather than detailing specific antidotes.

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Many of the clinical manifestations for acute stress are attributed to activation of the sympathetic nervous system and are mediated by:

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Naxlex Comprehensive Predictor Exams

Correct Answer is ["A","C"]

Explanation

A nursing student is preparing to give a medication that has a boxed warning. The student asks the nurse what this means. What will the nurse explain about boxed warnings?

Correct Answer is C

Explanation

A patient asks a nurse why a friend who is taking the same drug responds differently to that drug. The nurse knows that the most common variation in drug response is due to differences in each patient’s:

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