Monoamine oxidase inhibitors are used to treat which of the following?

Choice A reason: Announcing campus security may reduce anxiety but does not address reunification. Acute stress elevates cortisol and amygdala activity, and without structured reunification, parents’ distress persists, as prefrontal cortex-mediated organization is needed for effective crisis management.

Choice B reason: Designating zones for reunification organizes chaos, reducing amygdala-driven panic and cortisol surges in parents and students. This structured approach engages prefrontal cortex planning, ensuring safe, efficient reunification, addressing the immediate emotional and logistical needs post-crisis.

Choice C reason: Metal detectors ensure safety but delay reunification, prolonging amygdala-driven anxiety and cortisol release. Parents searching independently may increase chaos, as lack of structured reunification hinders prefrontal cortex-mediated organization, making this less effective than zoning.

Choice D reason: Blocking parents with tape escalates distress by preventing reunification, heightening amygdala activity and cortisol levels. This approach disregards emotional needs, impairing prefrontal cortex-mediated coping, and is counterproductive to resolving the crisis efficiently and compassionately.

Choice A reason: Persistent depressive disorder responds better to SSRIs or psychotherapy, as MAOIs’ risk of hypertensive crises due to monoamine buildup limits their use. MAOIs increase serotonin, dopamine, and norepinephrine, but are reserved for severe cases due to complex neural interactions.

Choice B reason: MAOIs like phenelzine are used for treatment-resistant depression, where SSRIs fail, by increasing serotonin, dopamine, and norepinephrine via enzyme inhibition. This broad monoamine enhancement alters prefrontal-amygdala circuits, addressing severe depressive symptoms unresponsive to other treatments, making it the primary indication.

Choice C reason: Moderate depression is typically treated with SSRIs or SNRIs, which have safer profiles. MAOIs’ risk of serotonin and norepinephrine overload, causing hypertensive crises, makes them unsuitable for moderate cases, where less aggressive neural modulation is effective.

Choice D reason: Mild depression is managed with psychotherapy or SSRIs, not MAOIs, which risk serious side effects like tyramine-induced hypertensive crises due to excessive monoamine levels. MAOIs are reserved for severe, resistant cases, not mild neural dysregulation.